60025-44-7Relevant articles and documents
Expedient synthesis of gem-dialkylbenzyl heterocycles through olefinic hydroarylation
Lian, Yajing,Burford, Kristen,Londregan, Allyn T.
, p. 9509 - 9514 (2015)
A robust approach to gem-dialkylbenzyl heterocycles has been developed through a triflic acid-catalyzed hydroarylation of olefinic heterocycles. A broad range of substrates containing pyridine, quinoline, pyrazole, triazole and imidazole moieties are shown to be highly compatible with this method. This rapid construction of gem-dialkyl groups should be useful in the synthesis of drug-like molecules containing heterocyclic diversity and in the study of the gem-dialkyl effect.