60041-89-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
2-Amino-6-fluoro-N-phenylbenzamide is utilized as a key building block in the creation of various pharmaceuticals and agrochemicals. Its unique structure allows for the development of compounds with specific therapeutic or pesticidal properties, contributing to the advancement of medicine and agriculture.
Used in Drug Discovery:
As a component in the investigation of new drug candidates, 2-Amino-6-fluoro-N-phenylbenzamide plays a crucial role in the early stages of drug development. Its incorporation into experimental compounds can lead to the discovery of novel therapeutic agents with improved efficacy and safety profiles.
Used in Chemical Research and Development:
2-Amino-6-fluoro-N-phenylbenzamide also serves as a valuable reagent in chemical research and development. Its application in various chemical reactions and processes aids in the exploration of new synthetic pathways and the optimization of existing ones, fostering innovation in the chemical sciences.
Used in Biological Activity Studies:
Ongoing research is focused on examining the potential biological activity of 2-Amino-6-fluoro-N-phenylbenzamide. This探究 aims to uncover its pharmacological properties, which could lead to the identification of new therapeutic targets and the development of effective treatments for various diseases and conditions.

Upstream product

• 443-69-6 5-fluoro-1H-indole-2,3-dione 
• 62-53-3 aniline 
• 394-02-5 5-fluoro-2-nitrobenzoyl chloride 
• 320-98-9 5-fluoro-2-nitrobenzoic acid 
• 60041-90-9 5-fluoro-2-nitro-N-phenylbenzamide 

Downstream Products

• 1615253-60-5 (S)-(1-(6-fluoro-4-oxo-3-phenyl-3,4-dihydroquinazolin-2-yl)ethyl)carbamate tert-butyl ester 
• 1252684-59-5 (S)-2-(1-aminoethyl)-6-fluoro-3-phenylquinazoline-4(3H)-one 
• 60041-88-5 6-fluoro-3-phenylbenzo[d][1,2,3]triazin-4(3H)-one 
• 1429192-35-7 6-fluoro-2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one 

Relevant academic research and scientific papers

SUBSTITUTED AMINOPYRIMIDINE COMPOUNDS AND METHODS OF USE

The invention relates to the preparation and use of new aminopyrimidine derivatives as drug candidates in free form or in pharmaceutically acceptable salt form and formulations thereof for the modulation of a disorder or disease which is mediated by the activity of the PI3K enzymes. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of disorders or diseases, such as disorders of immunity and inflammation in which PI3K enzymes play a role in leukocyte function, and hyperproliferative disorders associated with PI3K activity, including but not restricted to leukemias and solid tumors, in mammals, especially humans.

Substituted aminopyrimidine compound and usage method and application thereof

The present invention relates to a substituted aminopyrimidine compound and a usage method and application thereof, and in particular to application of the novel aminopyrimidine compound and free-form salts or pharmaceutically acceptable salts and preparations thereof as the medicaments for the treatment of PI3-kinase abnormality-related disorder or diseases. The invention also relates to the pharmaceutical compositions comprising the compound, and application of the pharmaceutical compositions to the treatment of mammals, particularly for the treatment of PI3-kinase abnormality-related human disorder or diseases, such as treatment of PI3-kinase regulated immune and inflammatory diseases, wherein PI3-kinase plays a major role in leukocyte function, and the treatment of of PI3- kinase-related proliferative diseases including but not limited to leukemia and solid tumors.

Copper-catalyzed radical methylation/C-H amination/oxidation cascade for the synthesis of quinazolinones

A copper-catalyzed radical methylation/sp3 C-H amination/oxidation reaction for the facile synthesis of quinazolinone was developed. In this cascade reaction, dicumyl peroxide acts not only as a useful oxidant but also as an efficient methyl source. Notably, a methyl radical, generated from peroxide, was confirmed by electron paramagnetic resonance for the first time.