60045-62-7

Basic information

• Product Name: 5-(4-methylbenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• Synonyms: 4(5H)-pyrimidinone, 6-hydroxy-2-mercapto-5-[(4-methylphenyl)methylene]-, (5Z)-; 4,6(1H,5H)-Pyrimidinedione, dihydro-5-[(4-methylphenyl)methylene]-2-thioxo-; 5-(4-Methylbenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
• CAS NO: 60045-62-7
• Molecular Formula: C₁₂H₁₀N₂O₂S
• Molecular Weight: 246.285
• Mol File: 60045-62-7.mol
• Article Data: 7

Chemical Properties

• Density: 1.38g/cm³
• Refractive Index: 1.676
• CAS DataBase Reference: 5-(4-methylbenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-methylbenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione(60045-62-7)
• EPA Substance Registry System: 5-(4-methylbenzylidene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione(60045-62-7)

Safety Data

• Hazardous Substances Data: 60045-62-7(Hazardous Substances Data)

Upstream product

• 504-17-6 4,6-dihydroxy-2-mercaptopyrimidine 
• 104-87-0 4-methyl-benzaldehyde 

Downstream Products

• 1240506-94-8 (5Z)-2-(benzylthio)-5-(4-methylbenzylidene)pyrimidine-4,6(1H,5H)-dione 
• 1361480-26-3 C₃₄H₂₈N₄O₃S 

Relevant articles and documents

Verjuice as a green and bio-degradable solvent/catalyst for facile and eco-friendly synthesis of 5-arylmethylenepyrimidine-2,4,6-trione, pyrano[2,3-d]pyrimidinone and pyrimido[4,5-d]pyrimidinone derivatives

Verjuice (unripe grape juice), a natural mixture of organic acids, which is identified by pH-metric and TGA analysis, is efficiently used for the promotion of the synthesis of 5-arylmethylenepyrimidine-2,4,6-triones, via Knovenagel condensation reaction between barbituric or thiobarbituric acid and aldehydes. Verjuice is also employed for the effective synthesis of pyrano[2,3-d]pyrimidinone derivatives via a three-component reaction of barbituric acid or its thio analogue, aldehydes and malononitrile. In the same way, pyrimido[4,5-d]pyrimidinone derivatives are simply produced via the reaction of barbituric acid, aldehydes and urea or thiourea in the presence of verjuice. This green methodology rewards notable advantages including simple procedures, acceptable reaction times, easy work-up, high yields, circumventing the use of any expensive starting materials, volatile and hazardous organic solvents during the reaction and work-up process, and use of a natural, low-cost, reusable, and bio-degradable catalyst.

DABCO-based ionic liquids: Green and recyclable catalysts for the synthesis of barbituric and thiobarbituric acid derivatives in aqueous media

A new and straightforward method for the synthesis of 5-arylidine barbituric and thiobarbituric acids through a reaction between barbituric acid and its thio-analogue with aldehydes using 1,4-disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium dihydrogen sulfate ([DABCO](SO3H)2(HSO4)2) as an efficient catalyst has been reported. In this project, also the preparation of pyrano[2,3-d]-pyrimidinediones via the reaction of barbituric or thiobarbituric acid, malononitrile and aldehydes in the presence of this reagent and 1,4-disulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium chloride ([DABCO](SO3H)2(Cl)2) has been investigated. The structure of the products was characterized using IR, 1H NMR and 13C NMR spectroscopy. The present methodologies suggests several advantages such as ease of the preparation and handling of the catalysts, high yields, simple and green procedures, low cost, short reaction times, easy work-up and preformation of the reaction in water as a green solvent.

Nickel nanoparticles catalyzed knoevenagel condensation of aromatic aldehydes with barbituric acids and 2-thiobarbituric acids

An efficient route for the Knoevenagel condensation of aromatic aldehydes with barbituric acids and 2-thiobarbituric acids in the presence of polyvinyl pyrrolidone (PVP) stabilized Ni nanoparticles in ethylene glycol has been reported. A range of biologically important arylidene barbiturates were obtained in high yields (82-97%) in a very short reaction time. Graphical Abstract: A novel and highly efficient PVP-stabilized Ni nanoparticles catalyzed synthesis of arylidene barbiturates and arylidene 2-thiobarbiturates has been described.