60046-52-8

Upstream product

• 120674-43-3 3-tert-butyldimethylsilyloxy-β-ionylideneacetaldehyde 
• 120657-96-7 ethyl 3-tert-butyldimethylsilyloxy-β-ionylideneacetate 
• 14398-35-7 (3E)-4-(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)but-3-en-2-one 
• 39760-56-0 triethyl 3-methyl-4-phosphonocrotonate 
• 142739-15-9 2-Methyl-2-[(E)-2-(2,6,6-trimethyl-cyclohexa-1,3-dienyl)-vinyl]-[1,3]dioxolane 
• 142739-16-0 3-hydroxy-β-ionone 
• 121468-88-0 (-)-(2E,4E)-5-[(R)-4-(tert-butyldimethylsilyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]-3-methylpenta-2,4-dienal 
• 152187-06-9 (R)-5-(tert-butyldimethylsilyloxy)-2-[(trifluoromethanesulfonyl)oxy]-1,3,3-trimethylcyclohex-1-ene 
• 76686-30-1 all-trans-(3R)-3-Hydroxyretinsaeure 
• 41891-38-7 3-formyl crotonic acid ethyl ester 
• 128426-10-8 (2E,4E)-5-(tri-n-butylstannyl)-3-methylpenta-2,4-dien-1-ol 
• 875927-54-1 ethyl (-)-(R)-all-trans-3-(tert-butyldimethylsilyloxy)-retinoate 
• 875797-47-0 (-)-(2E,4E)-5-[(R)-4-(tert-butyldimethylsilyloxy)-2,6,6-trimethylcyclohex-1-en-1-yl]-3-methylpenta-2,4-dien-1-ol 
• 875797-48-1 (-)-(R)-all-trans-3-(tert-butyldimethylsilyloxy)retinol 

Downstream Products

• 6890-91-1 (3RS,all-E)-hydroxyretinal 
• 81600-87-5 all trans, 9-cis 3-hydroxyretinal 
• 115075-58-6 all trans, 13-cis 3-hydroxyretinal 
• 102918-00-3 all trans, 11-cis 3-hydroxyretinal 
• 6890-91-1 3-hydroxy-9-cis-retinal 
• 81583-45-1 C₂₉H₃₆N₂O₅S 
• 81600-84-2 3-diazoacetoxy-9-cis-retinal 
• 60046-53-9 (-)-(R)-all-trans-3-hydroxyretinal 
• 875927-53-0 (-)-(R)-13-cis-3-hydroxyretinal 

Relevant academic research and scientific papers

Synthesis of enantiopure C3- and C4-hydroxyretinals and their enzymatic reduction by ADH8 from Xenopus laevis

(R)-all-trans-3-hydroxyretinal 1, (S)-all-trans-4-hydroxyretinal 3 and (R)-all-trans-4-hydroxyretinal 5 have been synthesized stereoselectively by Horner-Wadsworth-Emmons and Stille cross-coupling as bond-forming reactions. The CBS method of ketone reduct

156. Synthese von optisch aktiven, natuerlichen Carotinoiden und strukturell verwandten Naturprodukten. VII. Synthese von (3R)-3-Hydroxyretinol, (3R)-3-Hydroxyretinal und (3R)-Hydroxyretinsaeure

The synthesis of (3R)-hydroxyretinol (7), (3R)-3-hydroxyretinal (9) and (3R)-3-hydroxyretinoic acid (5) according to the building principle C15+C5=C20 is reported utilizing the optically active C15-phosphonium salt 2 and the C5-aldehyde ester 3.

Optically active cyclohexane derivatives

A process for fermentatively hydrogenating and reducing ketoisophorone to produce optically active [4R,6R]-4-hydroxy-2,6,6-trimethyl-cyclohexanone useful as an intermediate in the production of optically active carotenoids and intermediates in the product