6005-59-0Relevant academic research and scientific papers
Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing
Kim, Heejin,Min, Kyoung-Ik,Inoue, Keita,Im, Do Jin,Kim, Dong-Pyo,Yoshida, Jun-Ichi
, p. 691 - 694 (2016/05/19)
In chemical synthesis, rapid intramolecular rearrangements often foil attempts at site-selective bimolecular functionalization.We developed a microfluidic technique that outpaces the very rapid anionic Fries rearrangement to chemoselectively functionalize iodophenyl carbamates at the ortho position. Central to the technique is a chip microreactor of our design, which can deliver a reaction time in the submillisecond range even at cryogenic temperatures.The microreactorwas applied to the synthesis of afesal, a bioactive molecule exhibiting anthelmintic activity, to demonstrate its potential for practical synthesis and production.
Synthesis and antifungal activity of aspirin derivatives
Gao, Sumei,Xu, Zhihong,Wang, Xuesong,Feng, Hui,Wang, Ling,Zhao, Yuanjiang,Wang, Yue,Tang, Xiaorong
, p. 7157 - 7159 (2015/04/22)
Using aspirin as a lead compound, a series of its derivatives (compounds 1-7) were designed and synthesized. Their activity of antipathogenic fungi of plants has been evaluated in the laboratory. The results showed that these compounds had good antifungal activity against Sclerotinia sclerotiorum, Helminthosprium maydis, Botrytis cinerea and Rhizoctonia solani. Among them, the inhibition of growth for compounds 1 and 2 against Helminthosprium maydis reached 92.5 and 91.6% at a concentration of 100 mg L-1, respectively, which was superior to carbendazim.
