6007-90-5Relevant academic research and scientific papers
Oligothiophene compounds inhibit the membrane fusion between H5N1 avian influenza virus and the endosome of host cell
Zhu, Zhibo,Liu, Shuwen,Yao, Zhili,Shen, Xiantian,Chen, Zhipeng,Liu, Xiangtao,Parquette, Jon R.,Liu, Shuwen
, p. 185 - 194 (2017/03/08)
Hemagglutinin (HA) which is essential for influenza viral infection and replication has become a target for the design of anti-influenza drugs. A novel series of oligothiophene compounds focused on the target were synthesized as specific inhibitors agains
Treatment of hyperthyroidism with 1,3-dihydro-1[2-(2-thienyl)alkyl]-2H-imidazole-2-thiones
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, (2008/06/13)
The use of 1-(thienylalkyl)imidazole-2-thione derivatives as antihyperthyroid agents are described herein. These compounds may be administered as a preparatory adjunct procedure when thyroidectomy or radioactive iodine therapy is the recommended therapy or as a primary therapy when surgical procedures is not recommended or long term therapy is advisabe.
NOVEL THIONE DOPAMINE BETA HYDROXYLASE INHIBITORS
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, (2008/06/13)
Imidazole-2-thione derivatives useful as antihypertensive agents are described herein. The compounds areobtained by cyclization of an appropriate open-chaincompound such as an appropriately substituted thiourea.
Novel imidazole dopamine beta hydroxylase inhibitors
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, (2008/06/13)
1,2-Disubstituted imidazoles useful as antihypertensive agents are described herein. The compounds are obtained from the appropriate 1-substituted imidazole which can be reacted with methyl oxalyl chloride to give the oxalyl derivative or it can be reacte
Phenyl substituted dipeptide amides
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, (2008/06/13)
The invention relates to novel substituted tyrosyl alanine dipeptide amides of the formula: STR1 and the pharmaceutically acceptable acid addition salts thereof wherein R1 is hydrogen, lower alkyl, hydroxy, --OCO2 lower alkyl, lower alkoxy, --O(CH2)n -phenyl with the phenyl optionally substituted by halogen, --NO2, --CN, --NH2 or lower alkyl wherein n is 1 to 4; R2 and R3 represent lower alkyl, halogen, or lower alkoxy, or either one of R2 or R3 is hydrogen and the other is lower alkyl, lower alkoxy or halogen; R4, R5, R6, R7, R8, and R9 may be the same or different and represent hydrogen or lower alkyl; R10 is selected from the group consisting of where ALK represents alkylene, thioalkylene, oxyalkylene, having 1 to 5 carbon atoms; alkenylene and alkynylene having 2 to 4 carbon atoms; and X represents pyridyl, pyrimidinyl, 9H-fluoren-9-yl, diphenylmethyl, thienyl, carboxy, lower alkoxy carbonyl, substituted phenyl wherein the phenyl substituent is amino, hydroxy, halogen, nitro, methylenedioxy, lower alkyl, carboxy, lower alkoxycarbonyl, lower alkoxy, carboxamide, diloweralkylamino or X represents phenyl, when ALK is not alkylene; or R10 is STR2 where p and q are independently 1 to 4; or R9 and R10 together with N is STR3 where r and t are independently 1 to 4; v represents an asymmetric carbon that may be racemic or have the D or L configuration; w represents an asymmetric carbon when R7 and R8 are not the same that may be racemic or have the D or L configuration. These compounds are useful as analgesic and/or antihypertensive compounds.
SULFONAMIDOTHIENYLCARBOXYLIC ACID COMPOUNDS
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, (2008/06/13)
Compounds represented by the formula STR1 wherein X is halogen, lower alkyl, arylalkyl, alkoxy or hydroxy; wherein the phenyl ring is mono or disubstituted, R' is--COOH or STR2 wherein R" is lower alkyl or aryl and n and m are independently zero, one, two
