600713-80-2

Upstream product

• 212118-11-1 3-methoxy-4-(2,2,2-trifluoroacetamido)benzoic acid 
• 2486-69-3 3-methoxy-4-aminobenzoic acid 

Downstream Products

• 600713-81-3 2,2,2-trifluoro-N-[4-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methoxy-5-nitro-phenyl]-acetamide 
• 600713-82-4 N-[5-amino-4-(2-hydroxymethyl-pyrrolidine-1-carbonyl)-2-methoxy-phenyl]-2,2,2-trifluoro-acetamide 
• 1620874-85-2 2-chloro-3-hydroxy-4-(4-methylbenzoylamino)-6-nitrobenzoic acid ethyl ester 
• 1620874-86-3 7-chloro-5-nitro-2-(p-tolyl)benzoxazole-6-carboxylic acid ethyl ester 
• 1620874-87-4 5-amino-7-chloro-2-(p-tolyl)benzoxazole-6-carboxylic acid ethyl ester 
• 1620874-75-0 2-(5-amino-7-chloro-2-(p-tolyl)benzoxazol-6-yl)propan-2-ol 
• 1620874-88-5 4-benzoylamino-5-hydroxy-2-nitrobenzoic acid ethyl ester 
• 1620874-89-6 4-benzoylamino-2-chloro-3-hydroxy-6-nitrobenzoic acid ethyl ester 
• 1620874-90-9 7-chloro-5-nitro-2-phenylbenzoxazole-6-carboxylic acid ethyl ester 
• 1620874-91-0 5-amino-7-chloro-2-phenylbenzoxazole-6-carboxylic acid ethyl ester 
• 1620874-76-1 2-(5-amino-7-chloro-2-phenylbenzoxazol-6-yl)propan-2-ol 
• 1620874-92-1 4-amino-5-hydroxy-2-nitrobenzoic acid hydrochloride 
• 1620874-83-0 4-amino-5-hydroxy-2-nitrobenzoic acid ethyl ester 
• 1620874-84-1 5-hydroxy-4-(4-methylbenzoylamino)-2-nitrobenzoic acid ethyl ester 

Relevant academic research and scientific papers

ALDEHYDE CONJUGATES AND USES THEREOF

The present invention provides compounds and methods of use thereof for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

Amino pyrimidine compound and preparation method and application thereof

The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.

NOVEL TRAPS IN THE TREATMENT OF MACULAR DEGENERATION

The present invention is directed to compounds of formula (A): pharmaceutical compositions, and methods of use for treating, reducing a symptom of or reducing the risk of macular degeneration.

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

We report the synthesis of novel A-C8/C-C2 amide-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers (4a and 4b) via convergent routes. These compounds lack the potent DNA interstrand cross-linking ability and resultant pronounced cytotoxicity of the known A-