60079-77-8Relevant articles and documents
Manganese/bipyridine-catalyzed non-directed C(sp3)–H bromination using NBS and TMSN3
Sneh, Kumar,Torigoe, Takeru,Kuninobu, Yoichiro
supporting information, p. 885 - 890 (2021/05/05)
A Mn(II)/bipyridine-catalyzed bromination reaction of unactivated aliphatic C(sp3)?H bonds has been developed using N-bromosuccinimide (NBS) as the brominating reagent. The reaction proceeded in moderate-to-good yield, even on a gram scale. The introduced bromine atom can be converted into fluorine and allyl groups.
JAK kinase inhibitor and application
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Paragraph 0301-0302; 0304-0306, (2018/09/08)
The present invention discloses a compound having the following general formula (I). The present invention also discloses a JAK kinase inhibitor comprising the compound and application of the compoundin preparation of a medicament for treating JAK-associated diseases. The JAK kinase inhibitor can inhibit the biological activities of JAK1, JAK2, JAK3 and TYK2 kinases involved in various kinds of signal transduction, can effectively treat various inflammatory diseases and various JAK-mediated signal transduction-driven diseases, and has a very broad application prospect.
Modulators of methyl modifying enzymes, compositions and uses thereof
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Page/Page column 268; 269, (2015/12/26)
Agents for modulating methyl modifying enzymes, compositions and uses thereof are provided herein.