6008-38-4Relevant articles and documents
Enzymatic desymmetrization of prochiral 2,3-bis(acetoxymethyl)bicyclo [2.2.1]hepta-2,5-diene and 2,3-bis(hydroxymethyl)bicyclo[2.2.1]hepta-2,5- diene
Ranchoux, Magali,Brunel, Jean-Michel,Iacazio, Gilles,Buono, Gerard
, p. 581 - 587 (1998)
Enzymatic desymmetrization of the title compound 1 is reported using various commercially available lipases in hydrolysis and alcoholysis reactions or ester synthesis. In this area, lipase Amano AK (Pseudomonas sp.) proved to be the best lipase whatever the experimental conditions used. The monoacetate product 2 is indifferently obtained with more than 95% enantiomeric excess (ee) as the levorotatory enantiomer 2a or the dextrorotatory one 2b.
A Convenient Synthesis of 7-Substituted Norbornadienes
Luh, Tien-Yau,Lung, Ching Leung
, p. 57 - 58 (2007/10/02)
7-Substituted norbornadienes were conveniently synthesized from the adduct of nickelocene and dimethyl acetylenedicarboxylate