3-Hydroxy-isobutanoyl-CoA is an important intermediate in the catabolism of isoleucine, a branched-chain amino acid. It is formed during the first step of isoleucine degradation, where isoleucine is initially transaminated to form 2-keto-3-methylvaleric acid, which is then converted to 3-hydroxy-isobutanoyl-CoA by the enzyme 2-keto-3-methylvalerate dehydrogenase. 3-hydroxy-isobutanoyl-CoA plays a crucial role in the breakdown of isoleucine, as it is further metabolized through a series of reactions to produce acetyl-CoA, which can then enter the citric acid cycle for energy production. The conversion of 3-hydroxy-isobutanoyl-CoA to acetyl-CoA involves several enzymes, including 3-hydroxy-isobutyryl-CoA hydrolase and 3-methylcrotonyl-CoA carboxylase, which ultimately lead to the production of acetyl-CoA and the release of carbon dioxide.
6008-94-2
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Basic information
- Product Name: 3-hydroxy-isobutanoyl-CoA
- Synonyms:
- CAS NO:6008-94-2
- Molecular Formula:
- Molecular Weight: 853.632
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: 3-hydroxy-isobutanoyl-CoA(CAS DataBase Reference)
- NIST Chemistry Reference: 3-hydroxy-isobutanoyl-CoA(6008-94-2)
- EPA Substance Registry System: 3-hydroxy-isobutanoyl-CoA(6008-94-2)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 6008-94-2(Hazardous Substances Data)
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Check Digit Verification of cas no
The CAS Registry Mumber 6008-94-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,0 and 8 respectively; the second part has 2 digits, 9 and 4 respectively.Calculate Digit Verification of CAS Registry Number 6008-94:
(6*6)+(5*0)+(4*0)+(3*8)+(2*9)+(1*4)=82
82 % 10 = 2
So 6008-94-2 is a valid CAS Registry Number.
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6008-94-2Downstream Products
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3-hydroxy-isobutanoyl-CoA
