601-55-8

Basic information

• Product Name: 5α-cholest-1-en-3-one
• Synonyms: 5α-cholest-1-en-3-one
• CAS NO: 601-55-8
• Molecular Weight: 384.646
• Mol File: 601-55-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 5α-cholest-1-en-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5α-cholest-1-en-3-one(601-55-8)
• EPA Substance Registry System: 5α-cholest-1-en-3-one(601-55-8)

Safety Data

• Hazardous Substances Data: 601-55-8(Hazardous Substances Data)

Upstream product

• 566-88-1 dihydrocholesterone 
• 2516-50-9 2α-chloro-5α-cholestan-3-one 
• 68-12-2 N,N-dimethyl-formamide 
• 41602-10-2 2-bromocholestan-3-one 
• 1452-34-2 2α-bromo-5α-cholestan-3-one 
• 108-75-8 2,4,6-trimethyl-pyridine 
• 17697-12-0 benzeneseleninic anhydride 
• 1900-72-7 C₂₉H₅₀OS 

Downstream Products

• 571-40-4 5α-androst-1-ene-3,17-dione 
• 116027-95-3 5α-cholesten-(1)-one-(3)-semicarbazone 
• 566-44-9 cholestane-1-one 
• 5793-57-7 5α-cholest-1-en-3β-yl benzoate 
• 76043-43-1 C₃₄H₅₁NO₃S 
• 7485-18-9 4-aza-A-homo-5α-cholest-1-en-3-one 
• 191481-88-6 C₅₄H₇₀O₆S 
• 162460-20-0 1α-(dimethylphenylsilyl)-5α-cholestan-3-one 
• 566-88-1 (5α)-cholestan-3-one 
• 1923-42-8 5α-cholest-1-en-3-one-(2,4-dinitro-phenylhydrazone) 

Relevant articles and documents

Functionalisation of Saturated Hydrocarbons. Part 13. Futher Studies on the Gif Oxidation of Cholestane Derivatives

The oxidation of cholest-4-en-3-one by the GifIV system to give progesterone has been studied over the temperature range -40 to +80 deg C.The optimum temperature is ca. +20 deg C.Below 0 deg C the yield of progesterone diminishes and the formation of a new compound, 25-hydroxycholest-4-en-3-one, is observed.The latter has been synthesised from lithocholic acid.An unexpected major product of the oxidation was A-nor-5β-cholestan-3-one, identified by comparison with an authentic sample.

Removal of Thioacetal Protecting Groups by Benzeneseleninic Anhydride

A number of thioacetals were deprotected with benzeneseleninic anhydride in good yield.The reaction worked particularly well for hindered spiro-1,3-dithiolans of 2,2,6-trimethylcyclohexanone and fenchone, and in examples where other literature methods had failed.