60122-72-7

Usage

Uses

Used in Pharmaceutical and Biochemical Applications:
BETA-TBU-DL-ALANINE is used as a building block in the synthesis of peptide-based drugs, leveraging its enhanced stability and lipophilicity to improve the properties of the resulting compounds.
Used in Asymmetric Synthesis:
As a chiral auxiliary, BETA-TBU-DL-ALANINE is employed in asymmetric synthesis to control the stereochemistry of reactions, leading to the production of enantiomerically pure compounds, which is crucial for the development of pharmaceuticals with specific biological activities.
Used in Specialty Chemicals Production:
BETA-TBU-DL-ALANINE is utilized in the production of specialty chemicals, where its unique properties contribute to the creation of novel compounds with specific applications in various industries.
Used in Research and Development:
In the field of research, BETA-TBU-DL-ALANINE serves as a valuable tool for the development of new pharmaceuticals, aiding scientists in exploring its potential applications and optimizing its use in drug discovery processes.
Overall, BETA-TBU-DL-ALANINE is a versatile compound with diverse applications across the fields of chemistry, biochemistry, and medicine, offering enhanced properties and potential for innovation in these areas.

Upstream product

• 88319-39-5 2-carbamoyl-4,4-dimethylpentanoic acid 
• 479353-90-7 2-amino-4,4-dimethyl-pentanenitrile 
• 88319-38-4 2-cyano-4,4-dimethylpentanoic acid 
• 7065-46-5 3,3-dimethylbutanoic acid chloride 
• 2987-16-8 3,3-dimethylbutyrylaldehyde 
• 39168-28-0 (E)-2-cyano-4,4-dimethyl-pent-2-enoic acid 
• 88319-40-8 N-formyl-L-neopentylglycine 
• 88319-40-8 N-formyl-D-neopentylglycine 
• 34906-87-1 4,4-dimethyl-2-oxo-pentanoic acid 
• 57224-49-4 (Z)-2-Formylamino-4,4-dimethyl-pent-2-enoic acid ethyl ester 

Downstream Products

• 112674-65-4 acetyl-L-neopentylglycine 
• 57224-50-7 D-neopentylglycine 
• 57224-50-7 L-neopentylglycine 
• 79777-82-5 N-tert-butyloxycarbonyl-D-neopentylglycine 
• 79777-82-5 N-tert-butyloxycarbonyl-L-neopentylglycine 
• 88319-44-2 N-benzoyloxycarbonyl-L-neopentylglycine 
• 88319-46-4 N-2-nitrobenzenesulfenyl-L-neopentylglycine 
• 199170-91-7 N-acetyl-γ-methyl-d,l-leucine 
• 65302-98-9 2-hydroxy-4,4-dimethylpentanoic acid 
• 459836-80-7 C₁₄H₁₉NO₃ 

Relevant academic research and scientific papers

DL-neopentyl glycine intermediate and preparation method thereof and preparation method of derivative based on intermediate

The invention relates to the field of amino acid preparation, in particular to a DL-neopentyl glycine intermediate and a preparation method thereof and a preparation method of a derivative based on the intermediate. The preparation method of the DL-neopentyl glycine intermediate comprises an acetylation reaction, a condensation reaction, a hydrolysis reaction, an oximation reaction and a reductionreaction, and then a corresponding derivative is obtained through the acetylation reaction and resolution. According to the preparation method, the reaction time is shortened, the reaction is more thorough and the DL-neopentyl glycine can be obtained; two methods for preparing the derivative D-neopentyl glycine and the derivative L-neopentyl glycine are obtained at the same time, the prepared product is high in purity, secondary refining is not needed, the production cost is reduced, and industrial large-scale production is facilitated.

PEPTIDES CONTAINING A NEOPENTYLGLYCINE RESIDUE

Neopentylglycine (III, 2-amino-4,4-dimethylpentanoic acid) was synthesized in both enantiomeric forms.Using the conventional methods of peptide synthesis, L-prolyl-L-neopentylglycylglycine amide (VII), the diastereomeric cyclodipeptides cyclo(L-neopentylglycyl-L-prolyl) (IXa) and cyclo(D-neopentylglycyl-L-prolyl) (IXb) and also N-acetyl-L-neopentylglycine methylamide (X) were prepared as models for further studies on physical properties and conformation of peptides.