601454-53-9

Upstream product

• 744246-70-6 7-chloro-2-[4-(4'-methylphenoxybut-2'-ynylthio)][1]benzothiopyran-4-one 
• 112519-37-6 7-chloro-4-hydroxydithiocoumarin 
• 36763-49-2 1-chloro-4-(p-tolyloxy)but-2-yne 

Relevant academic research and scientific papers

Regioselective synthesis of pentacyclic heterocycles by sequential [3,3] sigmatropic rearrangement of 2-(4′-aryloxybut-2′-ynyl-mercapto)thiochromen-4-ones

A number of 4-aryloxymethyl-7-chlorothiopyrano[2,3-b]thiochromen-5(2H)-ones are regioselectively synthesized in 80-85% yield by the Claisen rearrangement of 2-(4′-aryloxybut-2′-ynylmercapto)thiochromen-4-ones in refluxing chlorobenzene for 3 h. These products are then subjected to a second Claisen rearrangement in refluxing N,N-diethylaniline for 6 h to give hitherto unreported pentacyclic heterocycles in 50-55% yield.