601472-84-8

Upstream product

• 346-47-4 2-(4'-fluorobenzyl)benzoic acid 

Downstream Products

• 361212-76-2 [2-(4-fluoro-benzyl)-phenyl]-methanol 
• 569657-05-2 2-(4-fluorobenzyl)-N-methoxybenzamide 
• 2707-59-7 sym. Bis-<2-(4-fluor-benzyl)-phenyl>-harnstoff 
• 779-77-1 2-(4-fluorobenzyl)aniline 

Relevant academic research and scientific papers

Triarylmethanes and their Medium-Ring Analogues by Unactivated Truce–Smiles Rearrangement of Benzanilides

Intramolecular nucleophilic aromatic substitution (Truce–Smiles rearrangement) of the anions of 2-benzyl benzanilides leads to triarylmethanes in an operationally simple manner. The reaction succeeds even without electronic activation of the ring that pla

PROCESS FOR THE PRODUCTION OF [2- (4-FLUORO-BENZYL) -PHENYL] -ACETIC ACID

The present invention relates to a novel process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid, a compound obtainable from phthalic anhydride. The process comprises the subsequent steps a) through e): a) reacting phthalic anhydride with fluorobenzene or a derivative thereof in appropriate reaction conditions; b) over reducing the product obtained in step a) at the ketone moiety; c) reducing the product obtained in step b) with sodium dihydro-bis (2- 15 methoxyethoxy) aluminate (Red-Al) to the corresponding alcohol ; d) chlorinat ing the alcohol obtained in step c) ; e) inserting CO into the product obtained in step d) through an appropriate Pd-containing catalytic system. In an alternative embodiment, the step e) is replaced by the steps f1) and f2) : f1) reacting the product obtained in step d) with sodium cyanide ; f2) hydro lysing the product obtained in step f1). The present invention provides a process for the production of [2-(4-fluoro-benzyl)- phenyl]-acetic acid which is suitable for industrial scale reactors (e.g. which is cleaner and more efficient). Also, [2-(4-fluoro-benzyl)-phenyl]-acetic acid is obtained as a crystalline material with a purity > 95%.

Synthesis of spirodienones by intramolecular ipso-cyclization of N-methoxy-(4-halogenophenyl)amides using [hydroxy(tosyloxy)iodo]benzene in trifluoroethanol

Spirodienones bearing the 1-azaspiro[4.5]decane ring system have been synthesized from N-methoxy-(4-halogenophenyl)amides by the intramolecular ipso attack of a nitrenium ion generated with [hydroxy(tosyloxy)iodo]-benzene in trifluoroethanol.