601501-43-3Relevant academic research and scientific papers
Controlling the oxygenation level of hemoglobin by using a synthetic receptor for 2,3-bisphosphoglycerate
Zhong, Zhenlin,Anslyn, Eric V.
, p. 3005 - 3008 (2007/10/03)
A designed synthetic receptor (1), which has guanidinium groups and a CuII center, is highly effective and selective for binding 2,3-bisphosphoglycerate (2,3-BPG) in physiological media (see picture). The affinity is high enough that the receptor can deprive hemoglobin of available 2,3-BPG, and thus control the active level of 2,3-BPG and the related oxygenation level of hemoglobin. Cu = Green, N = blue, C = gray, P = yellow, O = red.
