60153-49-3 Usage
Uses
Used in Research and Toxicology Studies:
MNPN is used as a research compound in toxicology studies to investigate the mechanisms of carcinogenesis and the effects of nitrosamines on human health. Its detection in the saliva of betel quid chewers highlights the potential health risks associated with the consumption of betel quid and provides valuable insights into the development of cancer prevention strategies.
Used in Environmental and Occupational Health Assessments:
MNPN can also be used as a biomarker in environmental and occupational health assessments to monitor exposure to nitrosamines in various settings, such as industrial workplaces or contaminated environments. This can help identify potential sources of exposure and implement measures to reduce the risk of cancer and other health issues related to nitrosamine exposure.
Reactivity Profile
A nitrile. These materials are incompatible with acids; mixing nitriles with strong oxidizing acids can lead to extremely violent reactions. Nitriles are generally incompatible with other oxidizing agents such as peroxides and epoxides. The combination of bases and nitriles can produce hydrogen cyanide. Nitriles are hydrolyzed in both aqueous acid and base to give carboxylic acids (or salts of carboxylic acids). These reactions generate heat. Peroxides convert nitriles to amides. Nitriles can react vigorously with reducing agents. Acetonitrile and propionitrile are soluble in water, but nitriles higher than propionitrile have low aqueous solubility. They are also insoluble in aqueous acids.
Health Hazard
ACUTE/CHRONIC HAZARDS: There is sufficient evidence that Propionitrile, 3-(methylnitrosamino). is an animal carcinogen.
Fire Hazard
Flash point data for Propionitrile, 3-(methylnitrosamino). are not available. Propionitrile, 3-(methylnitrosamino). is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic and tumorigenic data. When heated to
decomposition it emits toxic fumes of NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 60153-49-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,1,5 and 3 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 60153-49:
(7*6)+(6*0)+(5*1)+(4*5)+(3*3)+(2*4)+(1*9)=93
93 % 10 = 3
So 60153-49-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N3O/c1-7(6-8)4-2-3-5/h2,4H2,1H3
60153-49-3Relevant academic research and scientific papers
Nitrolysis of Tertiary Amines: Piperidines, Piperazines, Bisdimethylaminoalkanes, and Functionalized Methyldialkylamines
Boyer, Joseph H.,Kumar, Govindarajulu,Pillai, T. Perumal
, p. 1751 - 1754 (2007/10/02)
Preparative amounts of mono- and di-nitrosamines were obtained from aliphatic cyclic and acyclic tertiary monamines and diamines by treatment with dinitrogen tetraoxide in carbon tetrachloride at 0 - 45 deg C.N-Methyl- and N-ethyl-piperidines (1) and (2) gave N-nitrosopiperidine (15), but N-isopropyl- and N-t-butyl-piperidines (3) and (4) did not.N-Methyl-, N-ethyl-, N-isopropyl- and N-t-butyl-N'-methylpiperazines (5) - (8) gave N,N'-dinitrosopiperazine (22) (in 90 percent, 81 percent, 55 percent, and 8 percent yields, respectively) and the diamine (8) also gave N-t-butyl-N'-dinitrosopiperazine (23) (45 percent).The N'-nitroso and the N'-nitro derivatives of N-methylpiperazine were similarly converted into N,N'-dinitroso- and N-nitroso-N'-nitropiperazines (22) (45 percent) and (30) (53 percent).Bisdimethylaminoalkanes (Me2N)2(CH2)n (10) - (14) gave bismethylnitrosaminoalkanes 2(CH2)n (24) - (27) and dimethylnitrosamine (28): n=1 (0 percent, 90 percent); n=2 (68 percent, 0 percent); n=3 (48 percent, 43 percent); n=4 (41 percent, 38 percent); n=6 (58 percent, 35 percent). β-Dimethylaminopropionitrile (18), 1-methylnitrosamino-2-dimethylaminoethane (17), and α-dimethylaminoacetic acid (19) gave the corresponding nitrosoamines by replacement of an N-methyl group.
