60156-13-0

Upstream product

• 873-55-2 sodium benzenesulfonate 
• 5000-44-2 1-phenylsulfonyl-2-propanone 

Downstream Products

• 119320-25-1 3-Benzenesulfonyl-1-p-tolyl-5-p-tolylazo-1H-pyrazol-4-ol 
• 119293-29-7 3-Benzenesulfonyl-1-(3-chloro-phenyl)-5-(3-chloro-phenylazo)-1H-pyrazol-4-ol 
• 119293-19-5 3-Benzenesulfonyl-1-(4-bromo-phenyl)-5-(4-bromo-phenylazo)-1H-pyrazol-4-ol 
• 119293-25-3 5-amino-1-phenyl-3-phenylsulfonylpyrazol-4-ol 
• 119293-26-4 5-(N-benzylideneamino)-1-phenyl-3-phenylsulfonylpyrazol-4-ol 
• 119293-24-2 4-acetoxy-1-phenyl-5-phenylazo-3-phenylsulfonylpyrazole 
• 79908-92-2 1-(2-Oxo-4-methylthioazetidin-1-yl)-3-phenylsulphonylpropan-2-one 
• 119293-27-5 3-Benzenesulfonyl-1-(4-fluoro-phenyl)-5-(4-fluoro-phenylazo)-1H-pyrazol-4-ol 
• 119293-30-0 3-Benzenesulfonyl-1-(3,4-dichloro-phenyl)-5-(3,4-dichloro-phenylazo)-1H-pyrazol-4-ol 
• 119293-23-1 1-phenyl-5-phenylazo-3-phenylsulfonylpyrazol-4-ol 
• 119293-28-6 3-Benzenesulfonyl-1-(4-chloro-phenyl)-5-(4-chloro-phenylazo)-1H-pyrazol-4-ol 
• 119293-20-8 3-Benzenesulfonyl-1-(2,4-dibromo-phenyl)-5-(2,4-dibromo-phenylazo)-1H-pyrazol-4-ol 
• 77006-46-3 3-Benzenesulfonylmethyl-6,6-dimethyl-5,6-dihydro-imidazo[2,1-b]thiazole; hydrobromide 

Relevant academic research and scientific papers

Fungicidal 2-substituted-1-(1-imidazolyl)-propyl aryl sulfides, sulfoxides and sulfones

Compounds of the formula: STR1 wherein n is 0, 1 or 2; R1 is phenyl optionally substituted with 1 to 5 substitutents independently selected from halogen, lower alkyl, lower alkoxy, nitro, cyano, lower carbalkoxy or amino optionally substituted

THE PREPARATION, SPECTRAL PROPERTIES, STRUCTURES, AND BASE-INDUCED CLEAVAGE REACTIONS OF SOME α-HALO-β-KETOSULFONES

The halogenation of β-ketosulfones such as α-methylsulfonylacetophenone (1) and benzenesulfonylacetone (10) can be effected with sulfuryl chloride or pyridinium bromide perbromide.Regiochemical control can be achieved by control of stoichiometry and/or the reaction conditions.Detailed 1H and 13C nmr, and mass spectra are recorded for a series of halogenated β-ketosulfones, together with structures by X-ray crystallography for 1, 2-chloro-2-methylsulfonyl-1-phenylethanone (2), chloromethyl methyl sulfone (4), and α-chloroacetophenone (21).Results from these studies are used to suggest a reason for the difficulty associated with substitution reactions of α-halosulfones.

Effect of Structural Change on Acute Toxicity and Antiinflammatory Activity in a Series of Imidazothiazoles and Thiazolobenzimidazoles

The effect of structural change on the biological activity of a series of imidazothiazoles and thiazolobenzimidazoles is described.It was found that compounds with polar substituents at the 2 or 3 position of the ring system are less acutely toxic while maintaining antiinflammatory activity.Other structural changes, such as the incorporation of a gem-dimethyl substituent in the 6 position, increase acute toxicity and eliminate antiinflammatory activity.The compound with the best activity/toxicity ratio contains an alkyl sulfonyl substituent on the thiazole ring.The thiazolobenzimidazole analogues are more potent than the imidazole analogues.