60166-91-8

Basic information

• Product Name: 1,3-Benzenedicarbonyl dichloride, 5-[[(2S)-2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-
• CAS NO: 60166-91-8
• Molecular Formula: C13H8Cl2I3NO5
• Molecular Weight: 709.83
• Mol File: 60166-91-8.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenedicarbonyl dichloride, 5-[[(2S)-2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenedicarbonyl dichloride, 5-[[(2S)-2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-(60166-91-8)
• EPA Substance Registry System: 1,3-Benzenedicarbonyl dichloride, 5-[[(2S)-2-(acetyloxy)-1-oxopropyl]amino]-2,4,6-triiodo-(60166-91-8)

Safety Data

• Hazardous Substances Data: 60166-91-8(Hazardous Substances Data)

Upstream product

• 36394-75-9 (S)-2-acetoxypropanoyl chloride 
• 37441-29-5 5-amino-2,4,6-triiodoisophthalic acid dichloride 
• 35453-19-1 2,4,6-triiodo-5-aminoisophthalic acid 

Downstream Products

• 77868-44-1 C₁₆H₂₀I₃N₃O₇ 
• 60166-93-0 Iopamidol 

Relevant articles and documents

5-Amino-2,4,6-triiodisophthaloyl acid dichloride derivative and application thereof in synthesis of iopamidol impurities

The invention relates to a production method of iopamidol impurities, in particular to 5-amino-2,4,6-triiodisophthaloyl acid dichloride derivative and application thereof in synthesis of iopamidol impurities, and belongs to the technical field of medicine

Manufacture of a Triiodinated Contrast Agent

A new compound, (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid, of formula II (S)-5-(2-acetoxypropanamido)-2,4,6-triiodoisophthalic acid. Said new compound is of use for the production of triiodinated contrast agent, especially lopamidol, with low content of acetyl and hydroxyacetyl analogs. The new compound may be formed from 5-amino-2,4,6-triiodoisophtalic acid by acylating with (S)-1-chloro-1-oxopropan-2-yl acetate. The new compound may then be converted to the respective acid dichloride by reacting with a chlorinating reagent, which is a further object of the present invention, followed by the amidation with 2-amino-1,3-propanediol and acetate hydrolysis.

PROCESS FOR THE PREPARATION OF IODINATED CONTRAST AGENT

The present invention relies on a process for the preparation of non ionic iodinated contrast agents and, in more details, it relates to a process for the preparation of Iopamidol in high yields and with a high degree of purity. In more details, the invention discloses a process for the preparation of a compound of formula (III) comprising the 5 condensation reaction a compound of formula (II) with 2-amino-1,3-propandiol, being said reaction carried out in an aprotic dipolar solvent and in the presence of an alkaline or alkaline rare earth metal oxide or hydroxide.