60170-45-8

Upstream product

• 60170-37-8 1-<5'-O-<(4-Methoxyphenyl)diphenylmethyl>-2'-desoxy-β-D-ribofuranosyl>-6,7-diphenyllumazylyl(3'-5')thymidin-(2-cyanethyl)ester 
• 71477-98-0 Triethylammonium-<2-cyanethyl><1-<5'-O-<(4-methoxyphenyl)diphenylmethyl>-2'-desoxy-β-D-ribofuranosyl>-6,7-diphenyllumazin-3'>phosphat 
• 60170-47-0 1-<2'-deoxy-5'-O-(4-monomethoxytrityl)-β-D-ribofuranosyl>-6,7-diphenylpteridine-2,4(1H,3H)-dione 
• 60170-41-4 C₃₆H₃₆N₇O₁₂P 

Relevant academic research and scientific papers

Nucleotides, XI. - Synthesis and Properties of Dinucleoside Monophosphates with Thymidine and 1-(2'-Deoxy-β-D-ribofuranosyl)lumazines as Building Blocks

The synthesis of various dinucleoside monophosphates (6a-e) with thymidine (3a) and 1-(2'-deoxy-β-D-ribofuranosyl)lumazines (3b-d) as building blocks via the phosphotriester approach is described.The completely protected phosphotriesters (4a-e) as well as the partially deblocked intermediates (5a-e) have been isolated and characterized by physical methods.Intramolecular interactions in the free dinucleoside monophosphates 6a-e have been detected by the determination of the hypochromicities and measurement of CD spectra, revealing a small base-stacking effect.Enzymatic hydrolysis of the dinucleoside monophosphates with snake venom and spleen phosphodiesterase strongly depends on various structural features and is greatly retarded in presence of the 6,7-diphenyllumazine moiety as an aglycone.