O(2)'-methyl-5-carbamoylmethyluridine, also known as 5-Carbamoylmethyl-2'-O-methyluridine or ncm5Um, is a naturally occurring modified nucleoside found in tRNA. It is the result of modifications mostly of uridine in the anticodon at position 34 in the process to produce a mature tRNA. This modification plays a crucial role in the proper functioning of tRNA and has been studied in yeast.
60197-30-0
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Basic information
- Product Name: O(2)'-methyl-5-carbamoylmethyluridine
- Synonyms: O(2)'-methyl-5-carbamoylmethyluridine;5-Carbamoylmethyl-2'-O-methyluridine
- CAS NO:60197-30-0
- Molecular Formula: C12H17N3O7
- Molecular Weight: 315.27928
- EINECS: N/A
- Product Categories: N/A
- Mol File: 60197-30-0.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: O(2)'-methyl-5-carbamoylmethyluridine(CAS DataBase Reference)
- NIST Chemistry Reference: O(2)'-methyl-5-carbamoylmethyluridine(60197-30-0)
- EPA Substance Registry System: O(2)'-methyl-5-carbamoylmethyluridine(60197-30-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 60197-30-0(Hazardous Substances Data)
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60197-30-0 Usage
Uses
Used in Biomedical Research:O(2)'-methyl-5-carbamoylmethyluridine is used as a research tool for understanding the role of tRNA modifications in various biological processes. Its presence in tRNA has been linked to the regulation of protein synthesis and gene expression, making it an important molecule for studying the mechanisms of these processes.
Used in Pharmaceutical Development:
Due to its role in tRNA function, O(2)'-methyl-5-carbamoylmethyluridine has potential applications in the development of therapeutic agents targeting tRNA-related diseases. Its unique structure and function may provide insights into the design of drugs that modulate tRNA activity and have therapeutic benefits.
Used in Diagnostics:
O(2)'-methyl-5-carbamoylmethyluridine can be used as a biomarker for certain diseases or conditions, as its levels or modifications may be indicative of specific biological states. Detection and analysis of this modified nucleoside in biological samples can aid in the diagnosis and monitoring of various health conditions.
Used in Synthetic Biology:
O(2)'-methyl-5-carbamoylmethyluridine can be employed in the field of synthetic biology for the design and construction of artificial tRNA molecules with specific functions. This can enable the development of novel biological systems and applications, such as the production of biotherapeutics or the engineering of cells with enhanced capabilities.
Check Digit Verification of cas no
The CAS Registry Mumber 60197-30-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,1,9 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.Calculate Digit Verification of CAS Registry Number 60197-30:
(7*6)+(6*0)+(5*1)+(4*9)+(3*7)+(2*3)+(1*0)=110
110 % 10 = 0
So 60197-30-0 is a valid CAS Registry Number.
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O(2)'-methyl-5-carbamoylmethyluridine
