60200-08-0

Upstream product

• 75-62-7 Bromotrichloromethane 
• 100-19-6 (4-nitrophenyl)ethanone 
• 56-23-5 tetrachloromethane 
• 716312-85-5 C₈H₈N₂O₂ 
• 28153-22-2 1-(4-nitrophenyl)ethanone hydrazone 
• 5264-26-6 1-(1,1-dichloroprop-1-en-2-yl)benzene 

Downstream Products

• 60200-10-4 1-acetamido-4-(2,2-dichloro-1-methyl ethenyl)-benzene 
• 77381-55-6 2-(4-Amino-phenyl)-dithiopropionic acid methyl ester 

Relevant academic research and scientific papers

The use of bromotrichloromethane in chlorination reactions

Carbon tetrachloride is no longer used as a common solvent due to its toxicity and harmful environmental impact. The synthesis of gem-dichloroalkenes from aldehydes by using triphenylphosphine typically requires carbon tetrachloride as a solvent. We report that stoichiometric bromotrichloromethane in acetonitrile can be used in place of solvent quantities of carbon tetrachloride in this transformation. Similarly, bromotrichloromethane in dichloromethane can be used for the room-temperature Appel reaction of benzyl alcohols to form benzyl chlorides, which is commonly carried out in refluxing carbon tetrachloride. Georg Thieme Verlag Stuttgart New York.

Catalytic olefination of carbonyl compounds. Effect of the structure of the carbonyl compound on the reaction

The mechanism of the novel reaction of catalytic olefination of carbonyl compounds was studied. The reaction involves the transformation of hydrazones of aromatic aldehydes and ketones into the corresponding dichloroalkenes and symmetrical azines by the treatment with carbon tetrachloride in the presence of CuCl as a catalyst. The stability of intermediate diazoalkanes is the main factor determining the direction of the reaction. In the case of sufficiently stable diazoalkanes, other products can be formed under the reaction conditions along with the products of catalytic olefination.

Olefination of aromatic ketones: Synthesis of mono- and dihaloalkenes

A new simple and efficient transformation of various aromatic ketones to the corresponding halo (dihalo) alkenes is described. The reaction proceeds under mild conditions to give the target products in good yields.

Anthelmintic benzimidazoles

Benzimidazole compounds are disclosed which are substituted at the 2-position with a loweralkoxy carbonylamino group and at the 5-position with a halogenated loweralkenyl group or a halogenated loweralkoxy, loweralkylthio, loweralkylsulfinyl or loweralkyl