602275-33-2Relevant academic research and scientific papers
Generation and reactions of α-trifluoromethyl stabilized aziridinyl anion, a general synthetic precursor for stereospecific construction of α-amino-α-trifluoromethylated quaternary carbon
Yamauchi, Yoshihiro,Kawate, Tomomi,Itahashi, Hiromi,Katagiri, Toshimasa,Uneyama, Kenji
, p. 6319 - 6322 (2003)
Optically pure α-trifluoromethylated aziridinyl anions react with various electrophiles to give the corresponding optically pure 2-trifluoromethyl-2-substituted aziridines, which are general synthetic precursors for optically pure α-amino-α-trifluoromethylated compounds, such as trifluoromethylated α/β-amino acids, in good yields.
Preparation of optically pure α-trifluoromethyl-α-amino acids from N-tosyl-2-trifluoromethyl-2-alkyloxycarbonyl aziridine
Katagiri, Toshimasa,Katayama, Yousuke,Taeda, Mayuko,Ohshima, Takanori,Iguchi, Naomi,Uneyama, Kenji
, p. 9305 - 9311 (2012/01/03)
The preparation of optically pure α-trifluoromethyl-α-amino acids from N-tosyl-2-trifluoromethyl-2-alkyloxycarbonylaziridine is described. Optically pure aziridine was prepared with a 60% yield via three steps from optically pure 2,3-epoxy-1,1,1-trifluoro
