60242-82-2Relevant academic research and scientific papers
Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors
Chen, Chen,Nie, Yiming,Xu, Guangsen,Yang, Xinying,Fang, Hao,Hou, Xuben
, p. 2771 - 2783 (2019/05/15)
Bcl-2 family proteins, which divides into pro-apoptosis proteins and anti-apoptosis proteins, are involved in cell apoptosis progression. As numerous studies illustrated, targeting Bcl-2 family proteins is more and more attractive and practicable to cancer treatment. In this work, we designed and synthesized a series of indomethacin derivatives as new inhibitors for Bcl-2 family proteins. Our results of binding assay to Bcl-2 proteins, MTT assay and apoptotic assay indicated that some compounds had potent binding affinity to Bcl-2/Mcl-1 but not Bcl-XL. Furthermore, compound 8j showed improved anti-proliferative activity than known Bcl-2 inhibitor WL-276.
New Side-Chain Protecting Groups for Lysine and Tyrosine Suitable for Solid-Phase Peptide Synthesis
Salem, Ezzeldin M.,Schou, O.
, p. 62 - 64 (2007/10/02)
The syntheses of two new lysine and tyrosine derivatives, Boc-Lys(2-ClZ) and Boc-Tyr(2-BrBzl) have been described.Their use in the solid-phase peptide synthesis of the decapeptide Glu-Arg(NO2)-Gly-Phe-Phe-Tyr-Thr-Pro-Lys-Thr (I) corresponding to the seque
