60246-84-6

Basic information

• Product Name: 2-(2-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine
• Synonyms: 2-(2-Methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine; Methyl 2-(4-phenyl-2,3-dihydro-1,5-benzothiazepin-2-yl)phenyl ether
• CAS NO: 60246-84-6
• Molecular Formula: C₂₂H₁₉NOS
• Molecular Weight: 345.4574
• Mol File: 60246-84-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 490.1°C at 760 mmHg
• Flash Point: 250.2°C
• Density: 1.16g/cm³
• Vapor Pressure: 2.84E-09mmHg at 25°C
• Refractive Index: 1.629
• CAS DataBase Reference: 2-(2-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(60246-84-6)
• EPA Substance Registry System: 2-(2-methoxyphenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(60246-84-6)

Safety Data

• Hazardous Substances Data: 60246-84-6(Hazardous Substances Data)

Usage

Chemical class

Benzothiazepines

Type of compound

Heterocyclic

Structural features

A benzene ring fused to a thiazepine ring

Potential pharmacological properties

Yes

Possible applications

Treatment of various diseases and conditions

Relevance in research

Medicinal chemistry and drug discovery

Upstream product

• 137-07-5 2-amino-benzenethiol 
• 5416-70-6 2-methoxychalcone 

Downstream Products

• 156875-30-8 6-(2-methoxy-phenyl)-2,3,4a-triphenyl-5,6-dihydro-4aH-4-oxa-7-thia-11b-aza-dibenzo[a,c]cyclohepten-1-one 

Relevant articles and documents

Cycloaddition reaction of benzoheteroazepine: Synthesis of 4a,5,6,12-tetrahydro-1H-1,3-oxazino[3,2-d][1,5] benzothiazepin-1-ones and 1H,7H-1,3-oxazino[3,2-d][1,5] benzodiazepin-1-ones

2,3-Dihydro-1,5-benzothiazepines and 2,3-dihydro-1H-1,5-benzodiazepines reacted with α -carbonylketenes, generated from 2-diazo-1,3-diphenyl-1,3-propanedione and 2-diazo-1-phenyl-1,3-butandione by heating, to give [2+4] cycloadducts 4a,5,6,12-tetrahydro-1H-1,3-oxazinop[3,2-d] [1,5]-benzothiazepin-1-ones and 4a,5,6,12-tetrahydro-1H,7H-1,3-oxazino [3,2-d][1,5]-benzodiazepin-1-ones. The cycloaddition reactions showed different regioselectivities when different 1,5-benzoheteroazepines reacted with asymmetric 2-diazo-1-phenyl-1,3-butandione. The conformations of cycloadducts and cycloadducts reaction mechanism were described.