60246-86-8

Basic information

• Product Name: 2-(3-nitrophenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine
• CAS NO: 60246-86-8
• Molecular Formula: C₂₁H₁₆N₂O₂S
• Molecular Weight: 360.4289
• Mol File: 60246-86-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 520.7°C at 760 mmHg
• Flash Point: 268.7°C
• Density: 1.28g/cm³
• Vapor Pressure: 2.02E-10mmHg at 25°C
• Refractive Index: 1.675
• CAS DataBase Reference: 2-(3-nitrophenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-nitrophenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(60246-86-8)
• EPA Substance Registry System: 2-(3-nitrophenyl)-4-phenyl-2,3-dihydro-1,5-benzothiazepine(60246-86-8)

Safety Data

• Hazardous Substances Data: 60246-86-8(Hazardous Substances Data)

Usage

Classification

Dihydropyridine calcium channel blocker

Medical Use

Treatment of high blood pressure and angina (chest pain)

Mechanism of Action

Relaxes blood vessels and reduces the workload of the heart, lowering blood pressure and improving blood flow to the heart

Administration

Orally, in forms such as tablets and capsules

Safety Consideration

Potential side effects and interactions with other drugs; should be used under the guidance of a healthcare professional

Upstream product

• 614-48-2 (E)-3-nitrochalcone 
• 137-07-5 2-amino-benzenethiol 
• 614-48-2 3-nitrochalcone 

Relevant articles and documents

Facile synthesis of 1,5-benzothiazepines in water using tetrabutylammonium tribromide

A simple, environmentally benign, and efficient method was developed for the preparation of 1,5-benzothiazepines via a one-pot condensation reaction of 2-aminothiophenol with 1,3-diaryl-2-propenones using tetrabutylammonium tribromide as an efficient and versatile catalyst in water.

Synthesis of 1,5-benzothiazepines with microwave irradiation under solvent and catalyst-free conditions

Microwave irradiation of a,β-unsaturated ketones (chalcones) and o-aminothiophenol in the absence of solvent and catalyst provides a highly efficient methodology for the synthesis of 1,5-benzothiazepines in moderate to good yields.

Cycloaddition reaction of benzoheteroazepine: Synthesis of 4a,5,6,12-tetrahydro-1H-1,3-oxazino[3,2-d][1,5] benzothiazepin-1-ones and 1H,7H-1,3-oxazino[3,2-d][1,5] benzodiazepin-1-ones

2,3-Dihydro-1,5-benzothiazepines and 2,3-dihydro-1H-1,5-benzodiazepines reacted with α -carbonylketenes, generated from 2-diazo-1,3-diphenyl-1,3-propanedione and 2-diazo-1-phenyl-1,3-butandione by heating, to give [2+4] cycloadducts 4a,5,6,12-tetrahydro-1H-1,3-oxazinop[3,2-d] [1,5]-benzothiazepin-1-ones and 4a,5,6,12-tetrahydro-1H,7H-1,3-oxazino [3,2-d][1,5]-benzodiazepin-1-ones. The cycloaddition reactions showed different regioselectivities when different 1,5-benzoheteroazepines reacted with asymmetric 2-diazo-1-phenyl-1,3-butandione. The conformations of cycloadducts and cycloadducts reaction mechanism were described.