60254-84-4Relevant academic research and scientific papers
Arylation of phe and tyr side chains of unprotected peptides by a Suzuki-Miyaura reaction in water
Vilaro, Maria,Arsequell, Gemma,Valencia, Gregorio,Ballesteros, Alfredo,Barluenga, Jose
body text, p. 3243 - 3245 (2009/05/27)
(Chemical Equation Presented) An efficient arylation in water of tyrosine and phenylalanine side chains from unprotected iodopeptides is accomplished by using Suzuki-Miyaura cross-coupling processes. The method is compatible with the hydrophilic and thermolabile nature of biologically active peptides. Also of interest, the arylated tyrosine peptides can be accessed in one-pot mode starting from native peptides.
First aromatic electrophilic iodination reaction on the solid-phase: Iodination of bioactive peptides
Arsequell, Gemma,Espuna, Gemma,Valencia, Gregorio,Barluenga, Jose,Carlon, Raquel Perez,Gonzalez, Jose M.
, p. 7393 - 7396 (2007/10/03)
Direct iodination of Tyr residues of peptides anchored on solid supports was accomplished, for the first time, by aromatic electrophilic attack of iodonium ions provided by the IPy2BF4 reagent. Compatibility studies of the iodination with routine solid-phase synthesis protocols are reported.
