60260-75-5Relevant academic research and scientific papers
Enthalpic and entropic contributions to the conformational free energies of methylthio, methylsulfinyl, methylsulfonyl, phenylthio, phenylsulfinyl, and phenylsulfonyl [s(o)(n)r, n = 0, 1, 2; r = ch3, ph] groups in cyclohexane
Juaristi, Eusebio,Labastida, Victoria,Antunez, Sandra
, p. 969 - 973 (2007/10/03)
A variable-temperature NMR study of (cis-4-methylcyclohexyl)methyl sulfide (1), sulfoxide (2), and sulfone (3), as well as (cis-4- methylcyclohexyl)phenyl sulfide (4), sulfoxide (5), and sulfone (6) allowed determination of the thermodynamic parameters, ΔH°and ΔS°, for the title groups. Reproduction of the experimental results with Allinger's MM3 program was successfully accomplished in the case of the sulfoxide and sulfide groups. Nevertheless, modification of the original force field torsional parameters was required in order to adequately reproduce the experimentally observed behavior of the sulfonyl derivatives. Rationalization of the enthalpic and entropic contributions to ΔG°[S(O)(n)R, n = 0, 1, 2; R = CH3, Ph] is advanced in terms of the steric characteristics of these sulfurcontaining groups and the resulting rotameric populations in the axial and equatorial monosubstituted cyclohexanes.
