60277-40-9

Basic information

• Product Name: 4'-(AMINOMETHYL)-1,1'-BIPHENYL-4-OL
• Synonyms: RARECHEM AL BW 0127;4'-(AMINOMETHYL)-1,1'-BIPHENYL-4-OL;4'-(AMINOMETHYL)-BIPHENYL-4-OL;4-(Aminomethyl)-biphenyl-4-ol HCl
• CAS NO: 60277-40-9
• Molecular Formula: C₁₃H₁₃NO
• Molecular Weight: 199.25
• Mol File: 60277-40-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 370.0±30.0 °C(Predicted)
• Appearance: /
• Density: 1.150±0.06 g/cm3(Predicted)
• PKA: 9.89±0.26(Predicted)
• CAS DataBase Reference: 4'-(AMINOMETHYL)-1,1'-BIPHENYL-4-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4'-(AMINOMETHYL)-1,1'-BIPHENYL-4-OL(60277-40-9)
• EPA Substance Registry System: 4'-(AMINOMETHYL)-1,1'-BIPHENYL-4-OL(60277-40-9)

Safety Data

• Hazardous Substances Data: 60277-40-9(Hazardous Substances Data)

Upstream product

• 19812-93-2 4-Cyano-4'-hydroxybiphenyl 
• 60277-30-7 (4'-Methoxy-biphenyl-4-ylmethyl)-carbamic acid methyl ester 

Downstream Products

• 486434-89-3 N-(4'-hydroxybiphenyl-4-yl)methyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-imidazole-2-carboxylic acid amide 
• 862540-75-8 2-[3-(2-{[(2R)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl]amino}-2-methylpropyl)phenyl]-N-[(4'-hydroxybiphenyl-4-yl)methyl]acetamide 
• 486435-66-9 N-(4'-hydroxybiphenyl-4-yl)methyl-4-(4'-trifluoromethylbiphenyl-2-carbonylamino)-1-methyl-pyrrole-2-carboxylic acid amide 
• 60277-63-6 2-{4'-[(5-Chloro-2-methoxy-benzoylamino)-methyl]-biphenyl-4-yloxy}-2-methyl-propionic acid ethyl ester 
• 60277-64-7 2-Methyl-2-{4-(2-methoxy-5-chloro-benzamido-methyl)-biphenyl-4'-oxy}-propionic acid 
• 60277-65-8 2-Methyl-2-{4-[(2-methoxy-5-chloro-benzamido)-methyl]-biphenyl-4'-oxy}-propanol 
• 60277-34-1 4-[2-Methoxy-5-chloro-benzamido-methyl]-4'-hydroxy-biphenyl 

Relevant articles and documents

Purinenucleoside derivative modified in 8-position and medical use thereof

The present invention provides an 8-modified purinenucleoside derivative which is useful for diseases associated with an abnormality of plasma uric acid level. An 8-modified purinenucleoside derivative represented by the following formula (I), a prodrug thereof or a pharmaceutically acceptable salt thereof, or a hydrate or solvate thereof, is useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like. In the formula, n is 1 or 2; RA is a hydrogen atom or a hydroxyl group; R1 is a hydrogen atom, a hydroxyl group, a thiol group, an amino group or a chlorine atom; ring J represents an optionally substituted 2-naphthyl group, or a group represented by the following general formula (II) wherein Y represents a single bond or a connecting group; ring Z represents an optionally substituted aryl group or heteroaryl group or the like; and R2 to R4, P1 and Q represents a halogen atom, a cyano group or the like.

2-(6-AMINO-PYRIDIN-3-YL)-2-HYDROXYETHYLAMINE DERIVATIVES AS BETA 2-ADRENOCEPTORS AGONISTS

The invention relates to compounds of formula (1) and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such derivatives. The compounds according to the present invention are useful in