6028-35-9Relevant academic research and scientific papers
Application of ultrasound irradiation for the reactions of N-hydroxymethylation
Zhong,Song,Peng,Qian
, p. 3801 - 3807 (2007/10/03)
A convenient and high yield method for the N-hydroxymethylation of substituted phthalimide and benzimidazole under ultrasound irradiation is reported.
Behaviour of 2,3-dihydro-1H-benzo[d]imidazole-2-thione towards amines under Mannich-type condition
Hamama
, p. 269 - 271 (2007/10/03)
2,3-Dihydro-1H-benzo[d]imidazole-2-thione (1) was subjected to a Mannich reaction with either dimethylamine, urotropine, morpholine, thiomorpholine, (±) 3,3,5 trimethylhexahydroazepine, piperazine or p-bromoaniline and formalin in different molar ratios to afford the Mannich bases. The reactivity of the Mannich base 5a towards indole was also investigated. In addition the condensation of hydroxymethyl derivative 10 with morpholine, benzimidazole, p-bromoaniline, tryptamine and aminiothiazole was achieved.
