60283-74-1

Basic information

• Product Name: 2H-Indol-2-one, 1,3-dihydro-5-methyl-3-(phenylimino)-
• CAS NO: 60283-74-1
• Molecular Formula: C15H12N2O
• Molecular Weight: 236.273
• Mol File: 60283-74-1.mol

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 1,3-dihydro-5-methyl-3-(phenylimino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 1,3-dihydro-5-methyl-3-(phenylimino)-(60283-74-1)
• EPA Substance Registry System: 2H-Indol-2-one, 1,3-dihydro-5-methyl-3-(phenylimino)-(60283-74-1)

Safety Data

• Hazardous Substances Data: 60283-74-1(Hazardous Substances Data)

Upstream product

• 608-05-9 5-methyl-indole-2,3-dione 
• 62-53-3 aniline 

Downstream Products

• 1391950-20-1 5-methyl-3'-phenylspiro[3H-indole-3,2'-thiazolidine]-2,4'(1H)-dione 
• 1383715-74-9 C₂₇H₂₃N₃O₃ 
• 608-05-9 5-methyl-indole-2,3-dione 
• 62-53-3 aniline 
• 84919-26-6 4-Fluoro-benzoic acid [5-methyl-2-oxo-1,2-dihydro-indol-(3Z)-ylidene]-hydrazide 
• 67503-15-5 5-methyl-3',4'-diphenyl-1H,4'H-spiro[indole-3,5'-[1,2,4]oxadiazol]-2-one 

Relevant articles and documents

One-pot solvent free, green route to novel substituted spiro[oxindole-isoxazolidine] derivatives: novel candidates as antimicrobial agents

The environmentally benign catalyst and solvent-free synthesis of ketonitrones may not always be accomplished by simple condensation reactions. The occasional reports of green synthetic routes toward these compounds have been reported. The key features of

Ambient temperature synthesis of spiro[indoline-3,2′-thiazolidinones] by a DBSA-catalyzed sequential reaction in water

An energy-efficient eco-friendly methodology for the synthesis of a series of pharmacologically important spiro[indoline-3,2′-thiazolidinones] has been developed by the reaction of primary amines with various isatin derivatives and thioglycolic acid in the presence of p-dodecylbenzenesulfonic acid (DBSA) as an efficient Br?nsted acid surfactant combined catalyst in aqueous medium at 25 °C. This synthetic protocol demonstrates several advantages such as operational simplicity, energy-efficiency, good to excellent isolated yields, and the use of a preferred green solvent system for the preparation of desired products.

Remote activation of the nucleophilicity of isatin

The concept of the remote activation of reactivity was first applied in asymmetric organocatalysis. An isatin 3-phenylimine derivative acts as a donor in the thiourea catalyzed asymmetric addition to unsaturated 1,4-ketoesters, affording aza-Michael adducts in high enantiomeric purity and yield.

"On water" synthesis of spiro-indoles via Schiff bases

A fast, efficient, and clean "on water" synthesis of new Schiff bases and their conversion to spiro compounds under microwave irradiation, as well as in water, is reported. Indol-2,3-diones were reacted separately with various heterocyclic and aromatic am

Synthesis of 1′-aryl-2′-(2-oxoindolin-3-yl)spiro[indoline-3, 5′-pyrroline]-2,3′-dione via one-pot reaction of arylamines, acetone, and isatins

An efficient synthetic method for 1′-aryl-2′-(2-oxoindolin-3- yl)spiro[indoline-3,5′-pyrroline]-2,3′-diones was successfully developed via the one-pot domino reaction of arylamines, acetone, and isatins in acetic acid. The reaction mechanism involved the

Facile and highly diastereoselective synthesis of 3-aminooxindoles via AgOAc-catalyzed vinylogous Mannich reaction

A novel AgOAc-catalyzed vinylogous Mannich reaction between easily prepared imines 1 derived from isatins and trimethylsilyloxyfuran 2 (TMSOF) was developed. This method provided a facile synthetic route to get access to synthetically useful quaternary 3-aminooxindole in excellent yields (94-99%) and diastereoselectivities (>99:1).