60287-71-0

Usage

Uses

Used in Chemical Industry:
2-(3,5-DIMETHYLPHENOXY)ANILINE is used as a key intermediate in the synthesis of dyes and pigments for various applications, such as coloring textiles, plastics, and paints. Its unique structure allows for the creation of a wide range of colors and properties in the final products.
Used in Pharmaceutical Industry:
2-(3,5-DIMETHYLPHENOXY)ANILINE is used as a building block in the development of pharmaceutical compounds, particularly in the synthesis of certain drugs. Its chemical properties enable the formation of new molecular structures with potential therapeutic effects.
Used in Research and Development:
2-(3,5-DIMETHYLPHENOXY)ANILINE is utilized in research laboratories for the study of chemical reactions and the development of new synthetic methods. Its reactivity and structural features make it a valuable tool for exploring new chemical pathways and understanding reaction mechanisms.
Used in Environmental Applications:
Although 2-(3,5-DIMETHYLPHENOXY)ANILINE has potential environmental impact, it is also used in the development of environmentally friendly products, such as biodegradable dyes and pigments. Its chemical properties can be modified to improve the sustainability of the final products.

Upstream product

• 60287-57-2 1,3-dimethyl-5-(2-nitrophenoxy)benzene 
• 615-43-0 2-iodophenylamine 
• 108-68-9 3,5-Dimethylphenol 
• 1493-27-2 ortho-nitrofluorobenzene 
• 88-73-3 2-Chloronitrobenzene 

Downstream Products

• 860525-69-5 dichloro-[2-(3,5-dimethyl-phenoxy)-phenyl]-arsine 
• 60287-86-7 N-[2-(3,5-dimethyl-phenoxy)-phenyl]-formamide 
• 102478-90-0 benzoic acid-[2-(3,5-dimethyl-phenoxy)-anilide] 
• 860517-56-2 [2-(3,5-dimethyl-phenoxy)-phenyl]-arsonic acid 

Relevant academic research and scientific papers

Green alternative solvents for the copper-catalysed arylation of phenols and amides

Investigation of the use of green organic solvents for the Cu-catalysed arylation of phenols and amides is reported. Alkyl acetates proved to be efficient solvents in the catalytic processes, and therefore excellent alternatives to the typical non-green solvents used for Cu-catalysed arylation reactions. Solvents such as isosorbide dimethyl ether (DMI) and diethyl carbonate also appear to be viable possibilities for the arylation of phenols. Finally, a novel copper catalysed acyl transfer process is reported.

Additivity of substituent effects in aromatic stacking interactions

The goal of this study was to experimentally test the additivity of the electrostatic substituent effects (SEs) for the aromatic stacking interaction. The additivity of the SEs was assessed using a small molecule model system that could adopt an offset face-to-face aromatic stacking geometry. The intramolecular interactions of these molecular torsional balances were quantitatively measured via the changes in a folded/unfolded conformational equilibrium. Five different types of substituents were examined (CH3, OCH3, Cl, CN, and NO2) that ranged from electron-donating to electron-withdrawing. The strength of the intramolecular stacking interactions was measured for 21 substituted aromatic stacking balances and 21 control balances in chloroform solution. The observed stability trends were consistent with additive SEs. Specifically, additive SE models could predict SEs with an accuracy from ±0.01 to ±0.02 kcal/mol. The additive SEs were consistent with Wheeler and Houk's direct SE model. However, the indirect or polarization SE model cannot be ruled out as it shows similar levels of additivity for two to three substituent systems, which were the number of substituents in our model system. SE additivity also has practical utility as the SEs can be accurately predicted. This should aid in the rational design and optimization of systems that utilize aromatic stacking interactions.