603-17-8

Basic information

• Product Name: PHEOPHYTIN A
• Synonyms: PHEOPHYTIN A;,11s),4beta,21beta]]-;ramethyl-20-oxo-,3,7,11,15-tetramethyl-2-hexadecenylester,[3s-[3alpha(2e,7s;3,7,11,15-tetramethylhexadec-2-en-1-yl [3S-[3alpha(2E,7S*,11S*),4beta,21beta]]-14-ethyl-21-(methoxycarbonyl)-4,8,13,18-tetramethyl-20-oxo-9-vinylphorbine-3-propionate;PHENOPHYTINA;PHEOPHORBIDE A (SH);PHEOPHYTHIN A
• CAS NO: 603-17-8
• Molecular Formula: C55H74N4O5
• Molecular Weight: 871.2
• EINECS: 210-031-3
• Mol File: 603-17-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 1032.1±65.0 °C(Predicted)
• Appearance: /
• Density: 1.094±0.06 g/cm3(Predicted)
• CAS DataBase Reference: PHEOPHYTIN A(CAS DataBase Reference)
• NIST Chemistry Reference: PHEOPHYTIN A(603-17-8)
• EPA Substance Registry System: PHEOPHYTIN A(603-17-8)

Safety Data

• Hazardous Substances Data: 603-17-8(Hazardous Substances Data)

Usage

General Description

Pheophytin A is a chlorophyll derivative that is found in plants and algae. It is produced through the process of chlorophyll degradation, which occurs when chlorophyll molecules are broken down and replaced by pheophytin A. This chemical compound plays a crucial role in the photosynthetic process, absorbing light energy and transferring it to other molecules involved in the production of energy-rich compounds. It also has antioxidant properties and has been studied for its potential health benefits, including its anti-inflammatory and anti-cancer properties. Pheophytin A is of interest to researchers in the fields of botany, agriculture, and medicine for its diverse biological activities and potential applications in various industries.

Upstream product

• 39391-40-7 chlorophyll α 

Downstream Products

• 53321-11-2 chlorophyll-a 
• 33719-95-8 3-(9,14-diethyl-4,8,13,18-tetramethyl-20-oxo-3,4-didehydro-phorbin-3-yl)-propionic acid methyl ester 
• 24533-72-0 pyropheophorbide a 
• 29169-79-7 9,14-diethyl-3-(2-methoxycarbonyl-ethyl)-4,8,13,18-tetramethyl-20-oxo-3,4-didehydro-23H,25H-phorbine-21-carboxylic acid methyl ester 
• 15739-09-0 Cu(II)(pheophytin a) 
• 19660-77-6 chlorin e6 
• 6453-67-4 methyl pyropheophorbide a 
• 36151-60-7 methyl mesopyropheophorbide a 
• 36151-62-9 3-devinyl-3-ethyl pyropheophorbide-α 
• 15664-29-6 pheophorbide A 
• 5594-30-9 13-epi-phaeophorbide a methyl ester 
• 5594-30-9 methylpheophorbide a 
• 15592-17-3 chlorin e6 trimethyl ester 
• 15664-29-6 pheophorbide-a 

Relevant articles and documents

Synthesis of a chlorophyll-a derivative fused with an additional exo-five-membered ring and its optical properties

A C20-free chlorophyll-a derivative with an additional exo-five-membered ring was successfully prepared using an ethylene linkage at the C3- and C5-positions. A bromination at the C20-position was requisite for the cyclization of a 1-hydroxyethyl or vinyl group at the C3-position of methyl bacteriopheophorbide-d or methyl pyropheophorbide-a, respectively. By comparing optical properties of the cyclized product with those of its 3-ethyl uncyclized analog in a diluted dichloromethane solution, it was shown that the cyclization shifted the Qx and Bx absorption maxima to longer wavelengths and reduced the Stokes shift.

PHEOPHORBIDE-alpha CONJUGATES AND THEIR USES

The present invention relates to a pheophorbide-α conjugate or its salt, solvate or hydrate. The pheophorbide-α conjugate of the present invention exhibiting fluorescence upon its introduction into cells and degradation inhibits the survival of various cancer cells. Especially, the conjugate of pheophorbide-α and doxorubicin shows higher fluorescence intensity at lower pH (cancer environment). Therefore, the present composition for photodynamic therapy (PDT) of cancers is also very useful in detecting cancers. Interestingly, the anticancer effects of the present composition are dually exerted with help of both the photosensitizer and the anticancer drug of the present conjugates.

Methods for Preparing Chlorophyll a and Chlorin e6

The present invention relates to a method for preparing chlorophyll-a and chlorin e6. This invention extracts chlorophyll-a by use of undisrupted chlorella cells themselves, thereby preparing chlorin e6 from the chlorophyll-a extract. The high contents of chlorophyll-a may be obtained by the pretreatment procedure of chlorella cells themselves selected in this invention. The present method is performed according to relatively simple procedures, and is suitable in the mass production of chlorin e6.