603-99-6 Usage
Uses
Used in Pharmaceutical Industry:
11-Keto-pregnanetriol is used as an anti-inflammatory and immunosuppressive agent for the treatment of various inflammatory and autoimmune conditions. Its ability to modulate the immune system and reduce inflammation makes it a potential therapeutic option for conditions such as rheumatoid arthritis, lupus, and inflammatory bowel disease.
Used in Neurological Applications:
11-Keto-pregnanetriol is used as an anxiolytic and sedative agent for the management of stress and anxiety disorders. Its allosteric modulation of the GABA receptor helps to reduce anxiety levels and promote relaxation, making it a potential treatment option for conditions such as generalized anxiety disorder, panic disorder, and post-traumatic stress disorder.
Used in Drug Development:
11-Keto-pregnanetriol is used as a target for further research and drug development due to its unique biological properties. Its potential applications in treating inflammatory and autoimmune conditions, as well as managing stress and anxiety disorders, make it an interesting candidate for the development of new therapeutic agents.
Check Digit Verification of cas no
The CAS Registry Mumber 603-99-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 3 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 603-99:
(5*6)+(4*0)+(3*3)+(2*9)+(1*9)=66
66 % 10 = 6
So 603-99-6 is a valid CAS Registry Number.
InChI:InChI=1/C21H34O4/c1-12(22)21(25)9-7-16-15-5-4-13-10-14(23)6-8-19(13,2)18(15)17(24)11-20(16,21)3/h12-16,18,22-23,25H,4-11H2,1-3H3/t12-,13+,14+,15-,16-,18+,19-,20-,21-/m0/s1
603-99-6Relevant academic research and scientific papers
Synthesis of 3α,6β,17,20α-Tetrahydroxy-5β-pregnan-11-one 6-Hemisuccinate, a Hapten for Immunoassay of 3α,17,20α-Trihydroxy-5β-pregnan-11-one
Cooley, George,Kirk, David N.
, p. 1205 - 1212 (2007/10/02)
3α,6β,17,20α-Tetrahydroxy-5β-pregnan-11-one 6-hemisuccinate (4) has been synthesised by two distinct routes.In the first of these, introduction of a 6β-hydroxy substituent into 17α-hydroxypregn-4-ene-3,11,20-trione followed by catalytic hydrogenation of the Δ4-olefinic bond gave 6β,17α-dihydroxy-5β-pregnane-3,11,20-trione.The 5β-configuration was confirmed by an X-ray crystallographic analysis of the derived 6-hemisuccinate.Subsequent selective reduction at C-3 and C-20 by sodium borohydride in the presence of cerous chloride gave the required compound (4), although in low overall yield.To avoid the problem of non-specificity in the reduction at C-20, alternative routes were explored from precursors already possessing the essential 17,20α-diol system, protected as the isopropylidene derivative or by acetylation as appropriate.Hydroboration-oxidation of 3,3-ethylenedioxy-17,20α-isopropylidenedioxypregn-5-en-11-one gave the 6β-hydroxy derivative of 5β-configuration, verified by dehydration (POCl3-pyridine) to the 6-ene derivative.Further routine transformations including succinoylation of the 6β-hydroxy derivative, deprotection at C-3 and in the side chain, and reduction of the 3-oxo group, gave the required compound (4).
