603038-73-9Relevant academic research and scientific papers
Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead
Du,Matsushima,Spyvee,Goto,Shirota,Gusovsky,Chiba,Kotake,Yoneda,Eguchi,DiPietro,Harmange,Gilbert,Li,Davis,Jiang,Zhang,Pelletier,Wong,Sakurai,Yang,Ito-Igarashi,Kimura,Kuboi,Mizui,Tanaka,Ikemori-Kawada,Kawakami,Inoue,Kawai,Kishi,Wang
supporting information; scheme or table, p. 6196 - 6199 (2010/06/19)
With bioactivity-guided phenotype screenings, a potent anti-inflammatory compound f152A1 has been isolated, characterized and identified as the known natural product LL-Z1640-2. Metabolic instability precluded its use for the study on animal disease model
MACROCYCLIC COMPOUNDS USEFUL AS PHARMACEUTICALS
-
Page/Page column 90, (2010/02/07)
The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof and methods for the use thereof in the treatment of various disorders including inflammatory or autoimmune disorders, and disorders involving malignancy or increased angiogenesis, wherein R1 -R11, t, X, Y, Z, and n are as defined herein.
