603039-06-1Relevant academic research and scientific papers
Discovery of a potent, metabolically stabilized resorcylic lactone as an anti-inflammatory lead
Du,Matsushima,Spyvee,Goto,Shirota,Gusovsky,Chiba,Kotake,Yoneda,Eguchi,DiPietro,Harmange,Gilbert,Li,Davis,Jiang,Zhang,Pelletier,Wong,Sakurai,Yang,Ito-Igarashi,Kimura,Kuboi,Mizui,Tanaka,Ikemori-Kawada,Kawakami,Inoue,Kawai,Kishi,Wang
supporting information; scheme or table, p. 6196 - 6199 (2010/06/19)
With bioactivity-guided phenotype screenings, a potent anti-inflammatory compound f152A1 has been isolated, characterized and identified as the known natural product LL-Z1640-2. Metabolic instability precluded its use for the study on animal disease model
