603044-74-2Relevant academic research and scientific papers
Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III
Shen, Yongchun,Boivin, Roch,Yoneda, Naoki,Du, Hong,Schiller, Shawn,Matsushima, Tomohiro,Goto, Masaki,Shirota, Hiroshi,Gusovsky, Fabian,Lemelin, Charles,Jiang, Yimin,Zhang, Zhiyi,Pelletier, Robert,Ikemori-Kawada, Megumi,Kawakami, Yoshiyuki,Inoue, Atsushi,Schnaderbeck, Matthew,Wang, Yuan
scheme or table, p. 3155 - 3157 (2010/09/18)
Inspired by natural product, LL-Z1640-2, clinical candidate, E6201 (22) was discovered in a medicinal chemistry effort through total synthesis. The modification on C14-position to N-alkyl substitution showed to be potent in vitro and orally active in vivo in anti-inflammatory assays.
