603045-12-1

Usage

Uses

Used in Organic Synthesis:
(S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane is used as a precursor in the synthesis of organosilicon compounds. The diphenylsilane group in (S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane makes it a valuable building block for the creation of more complex molecules, which can be further utilized in various chemical reactions and processes.
Used in Materials Science:
In the field of materials science, (S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane can be used as a building block for the development of new materials with specific properties. (S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane's unique structure, including the tert-butyl group and the but-3-yn-2-yloxy group, may contribute to the enhancement of certain material characteristics, such as stability, reactivity, or compatibility with other components.
Used in Pharmaceutical Industry:
(S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane may also find applications in the pharmaceutical industry, where it can be used as an intermediate in the synthesis of various drugs and drug candidates. (S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane's unique structure and functional groups can be exploited to design and develop novel therapeutic agents with improved efficacy and selectivity.
Used in Chemical Research:
In the realm of chemical research, (S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane can serve as a valuable tool for studying the properties and reactivity of silane compounds. Researchers can use (S)-(but-3-yn-2-yloxy)(tert-butyl)diphenylsilane to explore new reaction pathways, develop innovative synthetic strategies, and gain insights into the fundamental principles governing the behavior of organosilicon compounds.

Upstream product

• 2914-69-4 (S)-(-)-3-butyn-2-ol 
• 140903-06-6 di-tert-butylchlorophenylsilane 
• 1124259-74-0 C₂₀H₂₄Br₂OSi 

Downstream Products

• 1124258-69-0 (S)-4-((tert-butyldiphenylsilyl)oxy)pent-2-yn-1-ol 
• 1146545-52-9 (4R,5S,6R,1'S)-4-tert-butoxy-6-(1'-tert-butyldiphenylsilyloxy)-ethyl-1-azabicyclo[3.2.0]heptan-7-one 
• 1146545-67-6 (5R,6R,1'S)-6-(1'-tert-butyldiphenylsilyloxy)ethyl-1-azabicyclo-[3.2.0]heptan-7-one 
• 1146545-62-1 (4S,5R,6R,1'S)-4-tert-butoxy-6-(1'-tert-butyldiphenylsilyloxy)-ethyl-1-azabicyclo[3.2.0]heptan-7-one 
• 1146545-51-8 (4S,5R,6S,1'S)-4-tert-butoxy-6-(1'-tert-butyldiphenylsilyloxy)-ethyl-1-azabicyclo[3.2.0]heptan-7-one 
• 1357149-49-5 (S)-((4-bromobut-3-yn-2-yl)oxy)(tert-butyl)diphenylsilane 
• 1357059-49-4 (S)-N-allyl-N-(3-(tert-butyldiphenylsilyloxy)but-1-ynyl)-4-methylbenzenesulfonamide 
• 1393478-20-0 (2S,3S,5R,6R)-3-(benzyloxy)-2-(benzyloxymethyl)-6-((S)-1'-(tert-butyldiphenylsilyloxy)ethyl)-1-azabicyclo[3.2.0]heptan-7-one 
• 1413383-15-9 (2S,3S,4S,5S,6R)-3,4-di(benzyloxy)-2-(benzyloxymethyl)-6-((S)-1'-(tertbutyldiphenylsilyloxy)ethyl)-1-azabicyclo[3.2.0]heptan-7-one 
• 1413383-06-8 (2S,3R,4R,5S,6R)-3,4-di(benzyloxy)-2-(benzyloxymethyl)-6-((S)-1'-(tertbutyldiphenylsilyloxy)ethyl)-1-azabicyclo[3.2.0]heptan-7-one 
• 1423076-04-3 (S)-3-(3-((tert-butyldiphenylsilyl)oxy)but-1-yn-1-yl)oxazolidin-2-one 

Relevant academic research and scientific papers

The synthesis of unnatural α-alkyl- And α-aryl-substituted serine derivatives

The synthesis of α-aryl- and α-alkyl-substituted serine derivatives via [3,3]-sigmatropic rearrangement of allyl carbamates as a key step is reported. Allyl carbamates were obtained from the corresponding allyl alcohols. The former were prepared through three approaches. Aryl-substituted ones were synthesized via the Stille coupling reaction of aryl iodides with enantiomerically enriched vinyl stannanes. Conversely, alkyl-substituted allyl alcohols were prepared by an analogous strategy involving the Negishi coupling reaction of enantiomerically enriched vinyl iodides or by enzymatic kineric resolution of the corresponding racemic alcohols.

New general method for regio- and stereoselective allylic substitution with aryl and alkenyl coppers derived from grignard reagents

Allylic substitution with sp2-carbon reagents (aryl and alkenyl anions) was realized by using allylic picolinates and copper reagents derived from RMgBr and CuBr-Me2S to afford anti SN2 products regioand stereoselectively. Steric and electronic factors in the reagents and the size of the methylene substituents around the allylic moiety marginally affected the selectivity. The reaction system was compatible with alkyl reagents as well. Furthermore, the substitution was applied to construction of a quaternary center and synthesis of (-)-sesquichamaenol. Electron-withdrawing nature of the pyridyl group and chelation of the C(=O)-C5H4N to MgBr2 generated in situ were found to be responsible for the high efficiency of the substitution.