60307-27-9

Upstream product

• 122695-45-8 3-(2-(1-methyl-5-oxo-2-pyrrolidinyl)(benzylthio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 
• 122695-44-7 3-(2-(1-methyl-5-oxo-2-pyrrolidinyl)(cyclohexylthio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 
• 122695-43-6 3-(2-(1-methyl-5-oxo-2-pyrrolidinyl)(phenylthio)acetyl)-4(S)-isopropyl-1,3-thiazolidine-2-thione 
• 122695-53-8 1-methyl-5-oxopyrrolidin-2-yl acetate 
• 33545-50-5 1-methyl-5-ethoxy-2-pyrrolidinone 
• 122695-56-1 ethyl (R)-1-methyl-5-oxo-2-pyrrolidineacetate 
• 64-17-5 ethanol 
• 122695-45-8 (R)-5-[(R)-1-Benzylsulfanyl-2-((S)-4-isopropyl-2-thioxo-thiazolidin-3-yl)-2-oxo-ethyl]-1-methyl-pyrrolidin-2-one 
• 122695-43-6 (R)-5-[(R)-2-((S)-4-Isopropyl-2-thioxo-thiazolidin-3-yl)-2-oxo-1-phenylsulfanyl-ethyl]-1-methyl-pyrrolidin-2-one 

Relevant academic research and scientific papers

DIASTEREOSELECTIVE ALKYLATION OF CHIRAL TIN(II) ENOLATES ONTO CYCLIC ACYL IMINIUM IONS. ASYMMETRIC TOTAL SYNTHESIS OF (-)-SUPINIDINE

The scope and mechanism of the asymmetric alkylation of chiral tin(II) enolate 10 with cyclic acyl iminium ion 5 were investigated.An application of the reaction to the asymmetric synthesis of (-)-supinidine was also achieved.

NEW CHIRAL RECOGNITION OF CHIRAL TIN(II) ENOLATES TOWARD CYCLIC ACYL IMINIUM SPECIES. ASYMMETRIC TOTAL SYNTHESIS OF (-)-SUPINIDINE

Diastereoselective alkylation of chiral tin(II) enolates 1 onto cyclic acyl iminium ion 7 proceeded in a different chiral recognition mode from the case of 1 onto cyclic acyl imines 3.This new diastereoselective alkylation was efficiently utilized for an asymmetric total synthesis of (-)-supinidine (20).