603110-33-4Relevant academic research and scientific papers
Efficient synthesis of optically active α-substituted glutamate analogs possessing α-hydroxymethyl and α-alkoxymethyl groups
Kawasaki, Masanori,Namba, Kosuke,Tsujishima, Hidekazu,Shinada, Tetsuro,Ohfune, Yasufumi
, p. 1235 - 1238 (2003)
Highly enantioselective synthesis of (2R)-α-(hydroxymethyl)glutamate (1), a selective agonist of mGluR2 and 3, was achieved in short steps using an asymmetric version of the Strecker synthesis. This was converted into its α-methoxymethyl- and α-benzyloxymethyl derivatives 2 and 3, possible ligands as tools to investigate glutamate receptors, via protection of the sterically hindered amino group by means of phase transfer catalyst.
