603121-78-4Relevant articles and documents
Diastereoselective synthesis of 1-benzyltetrahydroisoquinoline derivatives from amino acids by 1,4 chirality transfer
Zawadzka, Anna,Leniewski, Andrzej,Maurin, Jan K.,Wojtasiewicz, Krystyna,Siwicka, Aleksandra,Blachut, Dariusz,Czarnocki, Zbigniew
, p. 2443 - 2453 (2007/10/03)
L-Amino acids (L-Ala, L-Phe, L-Val, L-Pro) were used as a source of chirality in the diastereoselective synthesis of tetrahydroisoquinoline derivatives. The key step was the Pictet-Spengler condensation of ketoamides 4 and 10, which proceeded under very m