60342-56-5

Upstream product

• 76385-65-4 N-phosphonoacetyl-L-aspartate de methyle 
• 82283-66-7 (S)-2-[2-(Dimethoxy-phosphoryl)-acetylamino]-succinic acid dimethyl ester 
• 76385-64-3 N-(dihydroxyphosphinyl)acetoyl-L-aspartic acid diethyl ester 
• 71259-19-3 N-(diethoxyphosphinoyl)acetyl-L-aspartic acid diethyl ester 
• 67036-33-3 N-chloroacetyl-L-aspartic acid 
• 118903-72-3 N-(Phosphonoacetyl)-L-asparaginsaeure-di-(p-nitrobenzyl)-P,P-dimethylester 
• 118903-73-4 N-(Phosphonoacetyl)-L-asparaginsaeure-di(p-nitrobenzyl)ester 
• 76385-75-6 N-bis (trimethylsilyl) phosphonoacetyl-L-aspartate d'ethyle 
• 76385-76-7 N-bis (trimethylsilyl) phosphonoacetyl-L-aspartate de methyle 
• 66368-60-3 N-chloroacetyl-L-aspartic acid diethyl ester 
• 76385-50-7 (+)-dimethyl (S)-2-(2-chloroacetylamino)succinate 
• 56-84-8 L-Aspartic acid 

Downstream Products

• 56-84-8 L-Aspartic acid 

Relevant academic research and scientific papers

N-(Phosphonoacetyl)-L-aspartic acid compounds and methods for their preparation

N-(Phosphonoacetyl)-L-aspartic acid (PALA) compounds, especially novel PALA compounds, and methods for their preparation in large amounts are disclosed. These methods include preparation of certain PALA compounds such as PALA dibenzyl ester, disodium PALA, and the cyclohexylamine salt of dibenzyl PALA.

Preparation of N-(phosphonoacetyl)-L-aspartic acid

Improved methods for preparation of the tetrasodium and disodium salts of N-(phosphonoacetyl)-L-aspartic acid (PALA) are disclosed. The present methods are well suited for preparation of these products in large amounts. Particular aspects of these methods include: (1) initial preparation of the PALA moiety as the dibenzyl ester; (2) the complete removal of impurities in the form of acetic acid and sodium acetate from disodium PALA by turbulent flow precipitation; and (3) preparation and purification of the cyclohexylammonium salt of dibenzyl PALA which ultimately results in a purer final product.