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6035-45-6

6035-45-6

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6035-45-6 Usage

Chemical Properties

yellowish-white to yellow powder

Uses

Different sources of media describe the Uses of 6035-45-6 differently. You can refer to the following data:
1. An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
2. Antianemic

Biological Activity

human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line

Check Digit Verification of cas no

The CAS Registry Mumber 6035-45-6 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 6,0,3 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 6035-45:
(6*6)+(5*0)+(4*3)+(3*5)+(2*4)+(1*5)=76
76 % 10 = 6
So 6035-45-6 is a valid CAS Registry Number.
InChI:InChI=1/C20H23N7O7.Ca.5H2O/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;;;;;;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);;5*1H2/q;+2;;;;;/p-2/t12?,13-;;;;;;/m0....../s1

6035-45-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name Calcium folinatc

1.2 Other means of identification

Product number -
Other names Leucovorin Calcium

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6035-45-6 SDS

6035-45-6Synthetic route

Leucovorin Calcium
6035-45-6

Leucovorin Calcium

folinic acid
58-05-9

folinic acid

Conditions
ConditionsYield
With hydrogenchloride In water at 6 - 10℃; for 4h; pH=2.8 - 3.2;n/a
With acetic acid In water at 2 - 12℃; pH=2.5 - 3.5;
Leucovorin Calcium
6035-45-6

Leucovorin Calcium

leucovorin zinc

leucovorin zinc

Conditions
ConditionsYield
With zinc acetate dihydrate In water at 40℃;2.5 g

6035-45-6Upstream product

6035-45-6Downstream Products

6035-45-6Relevant articles and documents

Process for the preparation and separation of diastereomeric salts of folinic acid

-

, (2008/06/13)

A process for the preparation, separation and purification of (6S) and (6R) diastereomers of folinic acid salts with at least dibasic amines is disclosed, which process comprises the hydrolysis of (6RS)-5,10-methenyl-5,6,7,8-tetrahydrofolic acid chloride hydrochloride with an at least dibasic amine and the subsequent separation of the diasteromeric salts.

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