6035-49-0

Basic information

• Product Name: 6,7,8-TRIMETHOXYCOUMARIN
• Synonyms: O,O-DIMETHYLFRAXETIN;6,7,8-TRIMETHOXYCOUMARIN;DIMETHYLFRAXETIN;DIMETHYLFRAXETIN, O,O-;DIMETHYLFRAXETIN, O,O-(RG);6,7,8-Trimethoxy-2H-1-benzopyran-2-one;Fraxetin dimethyl ether;Di-O-Methylfraxetin
• CAS NO: 6035-49-0
• Molecular Formula: C12H12O5
• Molecular Weight: 236.22
• EINECS: 200-485-9
• Product Categories: Coumarins;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract
• Mol File: 6035-49-0.mol
• Article Data: 6

Chemical Properties

• Melting Point: 104-105°C
• Boiling Point: 338.68°C (rough estimate)
• Flash Point: 183.3 °C
• Appearance: /
• Density: 1.249
• Vapor Pressure: 8.46E-07mmHg at 25°C
• Refractive Index: 1.5140 (estimate)
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6,7,8-TRIMETHOXYCOUMARIN(CAS DataBase Reference)
• NIST Chemistry Reference: 6,7,8-TRIMETHOXYCOUMARIN(6035-49-0)
• EPA Substance Registry System: 6,7,8-TRIMETHOXYCOUMARIN(6035-49-0)

Safety Data

• Statements: 22
• Safety Statements: 22-45
• Hazardous Substances Data: 6035-49-0(Hazardous Substances Data)

Usage

General Description

6,7,8-Trimethoxycoumarin is a chemical compound derived from the coumarin family, specifically a derivative of umbelliferone. It is a naturally occurring compound found in various plant species, such as the edible fruits of the Hyptis suaveolens plant. 6,7,8-Trimethoxycoumarin has been studied for its potential biological and pharmacological properties, including its antioxidant and antimicrobial activities. It is also being investigated for its potential use in pharmaceuticals, as it has shown promise as an antidiabetic agent and in the treatment of inflammation. Additionally, 6,7,8-Trimethoxycoumarin has been found to have potential as a natural UV-blocking agent, which makes it of interest to the cosmetic and skincare industries. Overall, this compound has shown great potential for various applications in the fields of medicine, cosmetics, and natural products.

InChI:InChI=1/C12H12O5/c1-14-9-6-8-7(4-5-10(13)17-8)11(15-2)12(9)16-3/h4-6H,1-3H3

Upstream product

• 186581-53-3 diazomethane 
• 107078-01-3 6-hydroxy-7,8-dimethoxycoumarin 
• 86-81-7 3,4,5-trimethoxy-benzaldehyde 
• 59481-63-9 2-hydroxy-3,4,5-trimethoxybenzaldehyde 
• 1099-45-2 ethyl (triphenylphosphoranylidene)acetate 
• 73252-53-6 3,4,5-trimethoxy-2-iodobenzaldehyde 
• 114371-81-2 6,7,8-triacetoxy-coumarin 
• 483-91-0 calycanthoside 
• 58970-71-1 fraxidin 8-O-β-D-glucopyranoside 
• 74-88-4 methyl iodide 
• 525-21-3 fraxidin 
• 574-84-5 7,8-dihydroxy-6-methoxy-2H-1-benzopyran-2-one 
• 486-21-5 isofraxidin 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 72023-44-0 2,3,4,5-tetramethoxybenzoic acid 

Relevant articles and documents

ERIOSIDE, A NEW COUMARIN GLUCOSIDE FROM LASIOSIPHON ERIOCEPHALUS

Key Word Index: Lasiosiphon eriocephalus; Thymelaeaceae; 6,8-dihydoxy-7-O-D-glucosyloxycoumarin.

Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents

This study investigated the gastroprotective efficacy of synthesized scoparone derivatives on experimentally induced gastritis and their toxicological safety. Six scoparone derivatives were synthesized and screened for gastroprotective activities against HCl/ethanol- and indomethacin-induced gastric ulcers in rats. Among these compounds, 5,6,7-trimethoxycoumarin and 6,7,8-trimethoxycoumarin were found to have gastroprotective activity greater than the standard drug rebamipide; 6-methoxy-7,8-methylenedioxycoumarin, 6-methoxy-7,8-(1-methoxy)-methylenedioxycoumarin, 6,7-methylenedioxycoumarin, and 6,7-(1-methoxy)-methylenedioxycoumarin were found to be equipotent or less potent that of rebamipide. Pharmacological studies suggest that the presence of a methoxy group at position C-5 or C-8 of the scoparone’s phenyl ring significantly improves gastroprotective activity, whereas the presence of a dioxolane ring at C-6, C-7, or C-8 was found to have decreased activity. In order to assess toxicological safety, two of the potent gastroprotective scoparone derivatives-5,6,7-trimethoxycoumarin and 6,7,8-trimethoxycoumarin-were examined for their acute toxicity in mice as well as their effect on cytochrome P450 (CYP) enzyme activity. These two compounds showed low acute oral toxicity in adult male and female mice, and caused minimal changes to CYP3A4 and CYP2C9 enzyme activity. These results indicate that compared to other scoparone derivatives, 5,6,7-trimethoxycoumarin and 6,7,8-trimethoxycoumarin can improve gastroprotective effects, and they have low toxicity and minimal effects on drug-metabolizing enzymes.

CHEMICAL STUDY OF PLANTS OF THE MONGOLIAN FLORA COUMARINS OF Salsola laricifolia

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