60355-66-0

Usage

Uses

Used in Pharmaceutical Industry:
[3,4-diacetyloxy-5-(5-methylsulfanyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)oxolan-2-yl]methyl acetate is used as a potential pharmaceutical compound for its unique structural features and functional groups, which may offer novel therapeutic applications and drug development opportunities.
Used in Chemical Research:
In the field of chemical research, [3,4-diacetyloxy-5-(5-methylsulfanyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)oxolan-2-yl]methyl acetate serves as a subject of study to explore its chemical properties, reactivity, and potential use in the synthesis of other complex molecules.
Used in Material Science:
[3,4-diacetyloxy-5-(5-methylsulfanyl-2,4,8,9-tetrazabicyclo[4.3.0]nona-2,4,7,10-tetraen-9-yl)oxolan-2-yl]methyl acetate may be utilized in material science for the development of new materials with specific properties, such as enhanced stability, reactivity, or selectivity, due to its unique molecular structure.

InChI:InChI=1/C17H20N4O7S/c1-8(22)25-6-12-13(26-9(2)23)14(27-10(3)24)17(28-12)21-15-11(5-20-21)16(29-4)19-7-18-15/h5,7,12-14,17H,6H2,1-4H3

Upstream product

• 74-93-1 methylthiol 
• 78586-33-1 4-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolo<3,4-d>pyrimidine 

Relevant academic research and scientific papers

Synthesis and Antiviral Activity of certain Carbamoylpyrrolopyrimidine and Pyrazolopyrimidine Nucleosides

Following our recent discovery that 9-β-D-ribofuranosylpurine-6-carboxamide (1) exhibits potent antiviral activity, we were prompted to synthesize certain pyrrolopyrimidine and pyrazolopyrimidine nucleoside containing a carbamoyl function (7a,b and 13).The key precursor, 7-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrrolopyrimidine-4-carbonitrile (8a), required for the synthesis of 7a was prepared from the corresponding 4-chloro analogue (4a).Reaction of 4a with methanethiol, followed by oxidation, gave the 4-methylsulfonyl derivative (6a), which with NaCl in DMF gave 8a.Alkaline hydrolysis of 8a provided 7a.Similarly, 7b was prepared from 4-chloro-1-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolopyrimidine (4b) via the carbonitrile intermediate 8b.Starting with thioformycin B or 7-chloro-3-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)pyrazolopyrimidine (10) and following the similar sequence of reactions, we obtained compound 13.The in vitro antiviral studies of these carbamoyl and certain related nucleosides indicated 7a to be a potent antiviral agent against vaccinia virus, whereas 13 was moderately active. 4-Chloro-7-β-D-ribofuranosylpyrrolopyrimidine was found to be one of the most active compounds against RVF, PICH, YF, and SF viruses in culture.