60373-71-9

Basic information

• Product Name: 1-(1-BENZYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE
• Synonyms: 1-(1-BENZYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE;1-[1-benzyl-1,2,3,6-tetrahydro-4-pyridinyl]-1,3-dihydro-2H-benzimidazol-2-one;1-(1-Benzyl-1,2,3,6-tetrahydro-4-pyridyl)-2-benzimidazolinone;1-(1-Benzyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-benzimidazol-2(3H)-one;1-Benzyl-4-(2-keto-1-benzimidazolinyl)-1,2,3,6-tetrahydropyridine;2-Benzimidazolinone, 1-(1-benzyl-1,2,3,6-tetrahydro-4-pyridyl)-;Brn 0623095;Einecs 262-202-7
• CAS NO: 60373-71-9
• Molecular Formula: C₁₉H₁₉N₃O
• Molecular Weight: 305.37366
• EINECS: 262-202-7
• Mol File: 60373-71-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.257g/cm3
• Refractive Index: 1.66
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-(1-BENZYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(1-BENZYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE(60373-71-9)
• EPA Substance Registry System: 1-(1-BENZYL-1,2,3,6-TETRAHYDRO-PYRIDIN-4-YL)-1,3-DIHYDRO-BENZOIMIDAZOL-2-ONE(60373-71-9)

Safety Data

• Hazardous Substances Data: 60373-71-9(Hazardous Substances Data)

Usage

General Description

1-(1-Benzyl-1,2,3,6-tetrahydro-pyridin-4-yl)-1,3-dihydro-benzoimidazol-2-one is a chemical compound that belongs to the class of benzimidazole derivatives. It is a synthetic organic compound that has potential pharmaceutical applications. The compound contains a benzene ring attached to a pyridine ring, and it also contains a benzimidazole ring. These structural features make it a potentially important compound for medicinal chemistry research. The compound may have biological activities such as enzyme inhibition or receptor modulation, and further research is needed to fully understand its potential uses in the field of pharmacology.

InChI:InChI=1/C19H19N3O/c23-19-20-17-8-4-5-9-18(17)22(19)16-10-12-21(13-11-16)14-15-6-2-1-3-7-15/h1-10H,11-14H2,(H,20,23)

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 

Relevant articles and documents

Rearrangement of spiro-benzimidazolines: preparation of N-alkenyl- and N-alkyl-benzimidazol-2-ones

A synthetically useful protocol has been developed for the preparation of highly functionalized N-alkenyl-benzimidazol-2-ones. Reaction of commercially available o-phenylenediamines with variously substituted cyclic ketones provides spiro-benzimidazolines. Treatment of these spiro-benzimidazolines with triphosgene in the presence of potassium carbonate results in rapid rearrangement and formation of N-alkenyl-benzimidazol-2-ones in modest to excellent yield for the two-step sequence. Extension of this methodology toward the preparation of a μ opiate receptor antagonist and droperidol, a potent antiemetic and antipsychotic agent, currently a marketed pharmaceutical is also described. Upon treatment of spiro-benzimidazolines with triphosgene in the presence of sodium triacetoxyborohydride, N-alkyl-benzimidazol-2-ones were formed.