60376-98-9

Upstream product

• 2212-05-7 4-chlorophenyl 2,3-epoxypropyl ether 
• 99-76-3 methyl 4-hydroxylbenzoate 

Downstream Products

• 60377-90-4 4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-N-hydroxy-benzamide 
• 60377-49-3 4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-benzoic acid 
• 70193-50-9 4-[3-(4-Chloro-phenoxy)-2-oxo-propoxy]-benzoic acid methyl ester 
• 60377-40-4 4-[3-(4-Chloro-phenoxy)-2-hydroxy-propoxy]-benzoic acid 2-methoxy-ethyl ester 

Relevant academic research and scientific papers

Silver nanoparticle-catalysed phenolysis of epoxides under neutral conditions: Scope and limitations of metal nanoparticles and applications towards drug synthesis

Chemo- and regio-selective epoxide phenolysis is reported for the first time under neutral condition catalysed by silver nanoparticles. Other metal nanoparticles (e.g., Au, Pd, Cu, In, and Ru) are less effective. The choice of solvent is critical with 2-propanol being the best followed by DEF. Amongst various stabilisers used (surfactants, PEGs, tetra-alkylammonium halides) the tetra-alkylammonium halides are found to be the most effective (TBAF > TBAB > TBACl > TBAI). The role of the silver nanoparticles is envisaged as synchronous mode epoxide-phenol dual activation via a cooperative network of coordination, anion-π interaction, and hydrogen bond. The silver nanoparticles are recovered and reused for five consecutive times. The reaction has been used for the synthesis of propranolol and naftopidil as a few representative cardiovascular drugs.

Synergistic dual activation catalysis by palladium nanoparticles for epoxide ring opening with phenols

Synergistic dual activation catalysis has been devised for epoxide phenolysis wherein palladium nanoparticles induce electrophilic activation via coordination with the epoxide oxygen followed by nucleophilic activation through anion-π interaction with the aromatic ring of the phenol, and water (reaction medium) also renders assistance through 'epoxide-phenol' dual activation.

Arene-carboxylic acid derivatives as antiseborrheic additives for cosmetic agents

The invention concerns cosmetic agents containing compounds of the general formula (I) STR1 in which R1, R2 and R3 represent independently of one another a hydrogen atom, an intermediate alkyl group with 3 to 10 carbon atoms, a halogen atom, preferably a chlorine atom, a hydroxy group, an aryl group, an alkoxy group with 1 to 20 carbon atoms, substituted, if needed, with aryl, hydroxy, amino, alkoxy as well as aryloxy groups, or a carboxyl group esterified with an intermediate-chain alkyl group with 2 to 12 carbon atoms or with an aralkyl group, or two of the radicals R1 --R3 represent a naphthalene ring together with the benzene ring, and Y stands for an alkoxy group with 1 to 12 carbon atoms or an aralkoxy group. The compounds are used in amounts of 0.01 to 20, preferably 1 to 10, percent by weight, calculated with regard to the total preparation.