60388-36-5 Usage
General Description
4-(trifluoromethyl)benzothiazol-2-amine is a chemical compound with the molecular formula C9H6F3N3S. It is a benzothiazole derivative with a trifluoromethyl group attached to the benzene ring. 4-(trifluoromethyl)benzothiazol-2-amine has potential applications in pharmaceutical research and drug development due to its structural and functional properties. It may be used as a building block for the synthesis of novel pharmaceuticals, particularly in the development of drugs targeting specific biological pathways or enzymes. Additionally, 4-(trifluoromethyl)benzothiazol-2-amine may also have applications in materials science and organic synthesis due to its unique chemical structure and reactive properties. Overall, this compound has promising potential for various scientific and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 60388-36-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,3,8 and 8 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 60388-36:
(7*6)+(6*0)+(5*3)+(4*8)+(3*8)+(2*3)+(1*6)=125
125 % 10 = 5
So 60388-36-5 is a valid CAS Registry Number.
InChI:InChI=1/C8H5F3N2S/c9-8(10,11)4-2-1-3-5-6(4)13-7(12)14-5/h1-3H,(H2,12,13)
60388-36-5Relevant articles and documents
Design, Synthesis, and Biological Evaluation of 4-Phenoxyquinoline Derivatives Containing Benzo[d]thiazole-2-yl Urea as c-Met Kinase Inhibitors
Lei, Hongrui,Hu, Gang,Wang, Yu,Han, Pei,Liu, Zijian,Zhao, Yanfang,Gong, Ping
, p. 651 - 661 (2016/08/27)
A series of novel 4-phenoxyquinoline derivatives containing the benzo[d]thiazole-2-yl urea moiety were synthesized and evaluated for their cytotoxicity against the HT-29, MKN-45, and H460 cell lines. The structures of the target compounds were confirmed by 1H NMR and MS spectra. Most of them showed moderate to excellent potency against the three tested cell lines. Especially, compound 23 was identified a promising agent (c-Met IC50 = 17.6 nM), showing the most potent anticancer activities with IC50 values of 0.18, 0.06, and 0.01 μM against the HT-29, MKN-45, and H460 cell lines, respectively. The docking results of 23 with the c-Met kinase model 3LQ8 showed a specific binding mode between the ligand and the target protein.
Substituted 2-aminobenzothiazoles and derivatives useful as cerebrovascular agents
-
, (2008/06/13)
A series of substituted 2-aminobenzothiazoles and derivatives useful for treating cerebrovascular disorders are disclosed. Also disclosed is a new method for treating such disorders.
