60398-91-6 Usage
Description
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride, also known as Bufuralol hydrochloride (Ro 3-4787 hydrochloride), is a potent non-selective, orally active β-adrenoreceptor antagonist with partial agonist activity. It is a CYP2D6 probe substrate, which makes it useful in the study and evaluation of the CYP2D6 enzyme.
Used in Pharmaceutical Industry:
(±)-alpha-[[(tert-butyl)amino]methyl]-7-ethyl-2-benzofuranmethanol hydrochloride is used as a CYP2D6 substrate for the study and evaluation of the CYP2D6 enzyme. This application is crucial in understanding the enzyme's role in drug metabolism and its potential impact on the efficacy and safety of various medications.
Biochem/physiol Actions
Bufuralol hydrochloride is known to be a non-specific β-receptor inhibitor that has an affinity for β 1 and β 2 receptors. Furthermore, studies have reported that bufuralol hydrochloride can decrease isoproterenol peripheral resistance.
in vitro
Bufuralol is widely used in the characterization of CYP2D6 activity, and possesses aromatic rings and a basic nitrogen that are characteristic of CYP2D6 substrates.
in vivo
Bufuralol metabolism mediated by NADPH exhibits biphasic kinetics and is less efficient than that observed in the presence of cumene hydroperoxide (CuOOH) in and monkey intestines, in agreement with the observations in the livers.
references
[1] fothergill ga, francis rj, hamilton tc, osbond jm, parkes mw. bufuralol, a new beta-adrenoceptor blocking agent. experientia. 1975 nov 15;31(11):1322-3.[2] pringle, t. h.,francis, r.j.,east, p.b., et al. pharmacodynamic and pharmacokinetic studies on bufuralol in man. br.j.clin.pharmac. 22, 527-534 (1986).
Check Digit Verification of cas no
The CAS Registry Mumber 60398-91-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,3,9 and 8 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 60398-91:
(7*6)+(6*0)+(5*3)+(4*9)+(3*8)+(2*9)+(1*1)=136
136 % 10 = 6
So 60398-91-6 is a valid CAS Registry Number.