60399-05-5Relevant academic research and scientific papers
Ready N-alkylation of enantiopure aminophenols: Synthesis of tertiary aminophenols
Cimarelli, Cristina,Palmieri, Gianni,Volpini, Emanuela
, p. 6089 - 6096 (2007/10/03)
A regioselective indirect alkylation of aminophenols to enantiopure tertiary aminophenols, which are useful chiral ligands for metal-catalysed asymmetric reactions, is reported. This very simple synthetic methodology, through reduction or alkylation of an intermediate benzoxazine, was performed in mild conditions, suitable for the conservation of the configuration of the stereogenic centres. Some crystalline aminophenols show the phenomenon of 'crystallization-induced asymmetric transformation'.
Syntheses d'aminoalcools-1,3 ou d'aminophenols-1,3 par reduction d'enaminones ou d'iminophenols par les hydrures metalliques. Etude structurale par infrarouge et RMN des aminoalcools-1,3 bisecondaires diastereomeres
Maroni, Pierre,Cazaux, Louis,Tisnes, Pierre,Zambeti,Marianthie
, p. 179 - 186 (2007/10/02)
Enaminones, obtained by reaction of a primary amine with a β-diketone, can take three tautomeric forms: keto-enamine Ia, keto-imine Ib and imino-enol Ic.In general the keto-enamine form Ia is the most stable.Thi
