60406-67-9Relevant academic research and scientific papers
Method for synthesizing 3-trifluoromethyl substituted 1,2,4-triazole compounds by taking glucose as carbon source
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Paragraph 0032-0039, (2022/01/12)
The invention discloses a preparation method of 3-trifluoromethyl substituted 1,2,4-triazole compounds, wherein the preparation method comprises the following steps: adding trifluoromethanesulfonic acid, a 70% aqueous solution of tert-butyl hydroperoxide, water, trifluoroethyl imine hydrazide and glucose into an organic solvent, reacting at the temperature of 70-90 DEG C for 2-4 hours, and after the reaction is completed, carrying out post-treatment to obtain the 3-trifluoromethyl substituted 1,2,4-triazole compounds. The preparation method has the advantages of mild conditions, simple operation, no need of anhydrous and anaerobic conditions, simple and easily available initial raw materials, especially glucose is a biomass raw material widely existing in the nature, the reaction efficiency is high, the reaction can be expanded to gram-level reaction, 1,2,4-triazole compounds having trifluoromethyl groups and substituted by different functional groups can also be synthesized through substrate design, and the applicability of the method is widened while the operation is convenient.
Preparation method of 3-trifluoromethyl substituted 1,2,4-triazole compound
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Paragraph 0033-0047, (2021/08/28)
The invention discloses a preparation method of a 3-trifluoromethyl substituted 1,2,4-triazole compound. The preparation method comprises the following steps: adding molybdenum hexacarbonyl, cuprous acetate, triethylamine, a molecular sieve, trifluoroethy
Oxidative Cyclization of Trifluoroacetimidohydrazides with D-Glucose for the Metal-Free Synthesis of 3-Trifluoromethyl-1,2,4-Triazoles
Lu, Shu-Ning,Yang, Hefei,Zhang, Jiajun,Chen, Zhengkai,Wu, Xiao-Feng
, p. 4982 - 4987 (2021/10/14)
A metal-free oxidative cyclization of readily available trifluoroacetimidohydrazides with D-glucose for the assembly of 3-trifluoromethyl-1,2,4-triazoles has been disclosed. D-glucose is applied as C1 synthon to provide methine source in the reaction. Control experiments have been conducted to shed light on the reaction mechanism. The synthetic utility of the protocol has been explored by the implementation of scale up reaction and the synthesis of the key skeleton of NKI-receptor ligand. (Figure presented.).
Acaricidal trifluoromethyl-1,2,4-triazoles
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, (2008/06/13)
3-Trihalomethyl-1,2,4-triazoles either unsubstituted or having substituents in the 4 and/or 5, 1 and/or 5, and 2 and/or 5 positions; and methods for their preparation. Some of the compounds show biological activity; others have acaricidal activity.
